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- W2342002014 abstract "Low-density lipoprotein receptor (LDLR) maintains lipid metabolism and its expression is regulated by Sterol Regulatory Element Binding proteins (SREBPs). This study was designed to investigate the effect of insulin, a mitogen on LDLR, SREBP-2 receptor expression and cell proliferation. Insulin was found to have a stimulatory effect on the expression of LDLR and its transcription factor SREBP-2. Fluorescent dye (Dil) labelling assay revealed significantly increased uptake of Dil-LDL in the presence of insulin. Insulin also showed increased rate of cell replication. These findings suggested that LDLR expression is enhanced in the presence of insulin, which in turn results in increased uptake of LDL into the cells causing increased cell proliferation. The elevated expression of SREBP-2 indicated the influence of insulin on the transcription of genes responsible for increased expression and activity of LDLR.Keywords: LDL receptor, SREBP-2, Atherosclerosis, LDL uptake and BrdUrd Assay." @default.
- W2342002014 created "2016-06-24" @default.
- W2342002014 creator A5041941036 @default.
- W2342002014 date "2015-03-11" @default.
- W2342002014 modified "2023-09-26" @default.
- W2342002014 title "Effect of Insulin on Expression of LDLR, SREBP-2 and Cell Proliferation in Chang (normal) Liver Cells" @default.
- W2342002014 hasPublicationYear "2015" @default.
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