Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342020007> ?p ?o ?g. }
- W2342020007 endingPage "154" @default.
- W2342020007 startingPage "139" @default.
- W2342020007 abstract "There is increasing evidence that angiogenesis, through new blood vessel formation, results in improved collateral circulation and may impact the long-term recovery of patients. In this study, we first investigated the preventive action of a 5-week pretreatment of MLC901, an herbal extract preparation derived from Chinese medicine, against the deleterious effects of ischemic stroke and its effects on angiogenesis in a model of focal ischemia in mice.The stroke model was induced by 60 min of middle cerebral artery occlusion followed by reperfusion. MLC901 was administered in the drinking water of animals (6 g/l) for 5 weeks before ischemia and then during reperfusion.MLC901 treatment increased the survival rate, reduced the cerebral infarct area and attenuated the blood brain barrier leakage as well as the neurologic dysfunction following ischemia and reperfusion. We provide evidence that MLC901 enhances endothelial cell proliferation and angiogenesis by increasing the number of neocortical vessels in the infarcted area. MLC901 regulates the expression of hypoxic inducible factor 1α and its downstream targets such as vascular endothelial growth factor and angiopoietins 1 and 2. This work also shows that erythropoietin is an important player in the enhancement of angiogenesis by MLC901.These results demonstrate therapeutic properties of MLC901, in addition to those previously described, in stimulating revascularization, neuroprotection and repair of the neurovascular unit after ischemic stroke." @default.
- W2342020007 created "2016-06-24" @default.
- W2342020007 creator A5009977432 @default.
- W2342020007 creator A5050660601 @default.
- W2342020007 creator A5068045779 @default.
- W2342020007 creator A5071996474 @default.
- W2342020007 date "2016-01-01" @default.
- W2342020007 modified "2023-10-14" @default.
- W2342020007 title "MLC901 Favors Angiogenesis and Associated Recovery after Ischemic Stroke in Mice" @default.
- W2342020007 cites W128151115 @default.
- W2342020007 cites W1521155577 @default.
- W2342020007 cites W1522048223 @default.
- W2342020007 cites W1679229092 @default.
- W2342020007 cites W1876152197 @default.
- W2342020007 cites W1969369520 @default.
- W2342020007 cites W1974716477 @default.
- W2342020007 cites W1974962627 @default.
- W2342020007 cites W1978501014 @default.
- W2342020007 cites W1979109520 @default.
- W2342020007 cites W1980462025 @default.
- W2342020007 cites W1982829837 @default.
- W2342020007 cites W1984305500 @default.
- W2342020007 cites W1985247035 @default.
- W2342020007 cites W1995827857 @default.
- W2342020007 cites W1996660321 @default.
- W2342020007 cites W2001500938 @default.
- W2342020007 cites W2001988332 @default.
- W2342020007 cites W200667596 @default.
- W2342020007 cites W2016934775 @default.
- W2342020007 cites W2018039414 @default.
- W2342020007 cites W2019588794 @default.
- W2342020007 cites W2022932269 @default.
- W2342020007 cites W2026726977 @default.
- W2342020007 cites W2027052432 @default.
- W2342020007 cites W2028069038 @default.
- W2342020007 cites W2038108333 @default.
- W2342020007 cites W2038449972 @default.
- W2342020007 cites W2045850807 @default.
- W2342020007 cites W2047478188 @default.
- W2342020007 cites W2049028154 @default.
- W2342020007 cites W2053979603 @default.
- W2342020007 cites W2054170338 @default.
- W2342020007 cites W2054482783 @default.
- W2342020007 cites W2055197101 @default.
- W2342020007 cites W2062595499 @default.
- W2342020007 cites W2062694132 @default.
- W2342020007 cites W2063329712 @default.
- W2342020007 cites W2066888615 @default.
- W2342020007 cites W2071445982 @default.
- W2342020007 cites W2074041941 @default.
- W2342020007 cites W2083105809 @default.
- W2342020007 cites W2084498863 @default.
- W2342020007 cites W2091140224 @default.
- W2342020007 cites W2093062161 @default.
- W2342020007 cites W2114429672 @default.
- W2342020007 cites W2119562338 @default.
- W2342020007 cites W2121158877 @default.
- W2342020007 cites W2121836743 @default.
- W2342020007 cites W2125683177 @default.
- W2342020007 cites W2126329290 @default.
- W2342020007 cites W2129282529 @default.
- W2342020007 cites W2131950918 @default.
- W2342020007 cites W2135634299 @default.
- W2342020007 cites W2142463112 @default.
- W2342020007 cites W2143058635 @default.
- W2342020007 cites W2152215024 @default.
- W2342020007 cites W2153716005 @default.
- W2342020007 cites W2159186412 @default.
- W2342020007 cites W2164724870 @default.
- W2342020007 cites W2400268026 @default.
- W2342020007 cites W2246441098 @default.
- W2342020007 doi "https://doi.org/10.1159/000444810" @default.
- W2342020007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27099921" @default.
- W2342020007 hasPublicationYear "2016" @default.
- W2342020007 type Work @default.
- W2342020007 sameAs 2342020007 @default.
- W2342020007 citedByCount "24" @default.
- W2342020007 countsByYear W23420200072016 @default.
- W2342020007 countsByYear W23420200072017 @default.
- W2342020007 countsByYear W23420200072018 @default.
- W2342020007 countsByYear W23420200072019 @default.
- W2342020007 countsByYear W23420200072020 @default.
- W2342020007 countsByYear W23420200072021 @default.
- W2342020007 countsByYear W23420200072022 @default.
- W2342020007 countsByYear W23420200072023 @default.
- W2342020007 crossrefType "journal-article" @default.
- W2342020007 hasAuthorship W2342020007A5009977432 @default.
- W2342020007 hasAuthorship W2342020007A5050660601 @default.
- W2342020007 hasAuthorship W2342020007A5068045779 @default.
- W2342020007 hasAuthorship W2342020007A5071996474 @default.
- W2342020007 hasBestOaLocation W23420200071 @default.
- W2342020007 hasConcept C126322002 @default.
- W2342020007 hasConcept C127413603 @default.
- W2342020007 hasConcept C2776599846 @default.
- W2342020007 hasConcept C2777408375 @default.
- W2342020007 hasConcept C2778271429 @default.
- W2342020007 hasConcept C2778534260 @default.
- W2342020007 hasConcept C2780394083 @default.