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• W2342031830 abstract "Aim Diabetes-associated glucoregulatory derangements may precipitate atherogenesis in childhood and CVD risk, particularly with obesity. We aimed to delineate lipoprotein profile differences between children with type 1 and 2 diabetes who are overweight/obese. Methods Data were obtained from electronic medical records of patients ≥85th BMI percentile with type 1 (n = 159) and type 2 (n = 77) diabetes, ages 12–19 y. Group differences were evaluated by correlations and general linear modeling analysis, adjusting for BMI, HbA1c, and diabetes duration. Results There were no group differences in TC, LDL, or non-HDL. Fewer subjects with type 1 diabetes had low HDL (17 vs. 30%; P < 0.05). While no difference in HbA1c level was observed between groups, HbA1c was positively correlated with TC (P ≤ 0.0001), LDL (P ≤ 0.0001), non-HDL (P ≤ 0.0001), ApoB100 (P ≤ 0.0001), and LDL pattern B (P ≤ 0.0001). In adjusted models, apoB100 (85.4 vs. 91.3 mg/dl; P < 0.05) and incidence of LDL pattern B (21 vs. 42%; P < 0.01) were lower in subjects with type 1 diabetes. BMI was inversely correlated with HDL, HDL-2 and HDL-3 (all P ≤ 0.0001). The correlation of BMI with HDL-2 and HDL-3 were attenuated when evaluating subjects by diabetes type. Conclusions Despite having no difference in absolute LDL levels, children with type 2 diabetes were more likely to have small, dense LDL particle pattern, higher apo B100 and lower total HDL, HDL-2, and HDL-3 fractions. Furthermore, poor glycemic control was associated with abnormal lipoprotein profiles in patients with both type 1 and 2 diabetes." @default.
• W2342031830 created "2016-06-24" @default.
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• W2342031830 date "2016-05-01" @default.
• W2342031830 modified "2023-09-30" @default.
• W2342031830 title "Overweight adolescents with type 2 diabetes have significantly higher lipoprotein abnormalities than those with type 1 diabetes" @default.
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• W2342031830 doi "https://doi.org/10.1016/j.diabres.2016.03.004" @default.
• W2342031830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5373667" @default.
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