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- W2342034961 abstract "Purpose: This retrospective cohort study was designed to evaluate the effect of depression and anxiety on all-cause mortality after heart transplant. Methods: 130 patients with heart transplants enrolled at Kaiser Permanente, a large, integrated health care delivery system in Northern California, between June 2005 and December 2013 were included in a retrospective electronic chart review. Baseline variables included depression, anxiety, and cardiac risk factors in the year before heart transplant. Depression and anxiety were determined by diagnosis, psychotropic medication, and/or self-report instruments when available. Statistical tests included chi-square, t-tests and a KaplanMeier survival analysis. Results: For all patients, post-heart transplant overall one-year survival was 93.1%. The one-year survival for 50 patients without depression and anxiety was 100%, for 13 patients with anxiety only was 92.3% (p= 0.05), for 22 patients with depression only were 90.9% (p= 0.03), and for 45 patients with both depression and anxiety was 86.7% (p= 0.008). After adjustment, the presence of both depression and anxiety symptoms pre-heart transplant was shown as a significant predictor of mortality. The risk of all-cause mortality in heart transplant patients with preoperative depression and anxiety symptoms was highest within the two years (HR (95% CI)= 4.2 (1.1, 15.0), p= 0.03) followed by three years (HR (95% CI)= 3.7 (1.2, 11.9), p= 0.04) but not significant within five years post-heart transplant (HR (95% CI)= 2.0 (0.8, 5.3), p= 0.14) compared with patients without preoperative depression and anxiety symptoms. Conclusion: These findings suggest that depression and anxiety symptoms before heart transplant are associated with survival in the first year post heart transplant. A thorough psychosocial assessment and mental health treatment before heart transplant are recommended." @default.
- W2342034961 created "2016-06-24" @default.
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- W2342034961 date "2016-04-01" @default.
- W2342034961 modified "2023-10-04" @default.
- W2342034961 title "Effects of Pre-Transplant Depression and Anxiety Symptoms on Morbidity and Mortality Post-Heart Transplant: A Retrospective Cohort Study" @default.
- W2342034961 doi "https://doi.org/10.1016/j.healun.2016.01.404" @default.
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