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- W2342061660 abstract "Summary Autosomal dominant polycystic kidney disease (ADPKD) is hereditary cystic disorder with predominantly renal manifestation (large kidneys, flank pain, haematuria, hypertension and renal insufficiency). Some patients also present extrarenal symptoms, including hepatic cysts, cerebral and aortic aneurysms and colonic diverticula. The underlying genetic background of ADPKD is related to mutation of the PKD1 and PKD2 genes, coding specific protein products, known as polycystin 1 and 2. Renal failure develops mainly about the 6th decade of life. Apart from classic, symptomatic treatment of chronic kidney disease, several specific therapies, aimed to several pathways of disease mechanism, have been conducted in clinical trials, including use of ACE, mTOR, V2 receptor and cAMP inhibitors. None of those was universally effective in terms of complete stopping cysts growth and slowing deterioration of renal function or appeared to be not widely acceptable, due to high incidence of specific adverse events. Further investigation is required for developing effective and acceptable and friendly specific therapies of ADPKD." @default.
- W2342061660 created "2016-06-24" @default.
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- W2342061660 date "2015-09-26" @default.
- W2342061660 modified "2023-09-24" @default.
- W2342061660 title "Autosomal dominant polycystic kidney disease (ADPKD) - targets of pharmacotherapy and extrarenal complications" @default.
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