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- W2342100029 abstract "Galectin-3 is a 32- to 35-kDa member of the galectin family of b-galactoside-binding lectins, which is characterized by a carbohydrate recognition domain. Through its carbohydrate-binding function, it regulates cell growth, differentiation, and inflammation. It also plays a complex, context-dependent role in the kidneys. During development, it promotes nephrogenesis and is strongly expressed in the ureteric bud and its derivatives. An increase in the concentration of galectin-3 has been reported to be associated with fibrosis of the kidneys. Elevated levels of plasma galectin-3 are also associated with increased risks of rapid renal function decline, incident chronic kidney disease, and progressive renal impairment, and also with cardiovascular end points, infection, and all-cause mortality in patients with renal function impairment. This review discusses a general survey on galectin-3 expressions in nephrogenesis, kidney injury animal models, clinical renal diseases, renal transplantation and the potential role of galectin-3 for treatment in kidney disease." @default.
- W2342100029 created "2016-06-24" @default.
- W2342100029 creator A5059930981 @default.
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- W2342100029 date "2016-04-14" @default.
- W2342100029 modified "2023-10-11" @default.
- W2342100029 title "The Role of Galectin-3 in the Kidneys" @default.
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- W2342100029 doi "https://doi.org/10.3390/ijms17040565" @default.
- W2342100029 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4849021" @default.
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