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- W2342149722 abstract "Lichen planus (LP) is a cutaneous disease of unknown etiology. In the last decade several epidemiological studies have shown that there is a significant association between LP and chronic infection with hepatitis C virus (HCV). The aim of this study is to investigate if HCV infects in patients with LP lesions in order to gain further knowledge concerning a role for HCV in LP pathogenesis. Genomic and antigenomic HCV-RNA was detected using in situ hybridization on cutaneous biopsies from 32 patients with chronic hepatitis C HCV positive patients (biopsy obtained in 26 patients from healthy skin from the thorax, and in 6 patients from healthy facial skin), 24 patients with LP (5 with and 19 without HCV infection) and 6 healthy patients. HCV-RNA was detected in keratinocytes from 69.2% and 100% of the patients with chronic hepatitis C (healthy skin from the thorax and facial skin, respectively), in 100% of HCV positive patients with LP and in none of the HCV patients with LP. The percentage of keratinocytes containing genomic or antigenomic HCV-RNA was statistically lower (p < 0.05) in healthy skin (5.7 ± 3.5% and 2.7 ± 3.1% of keratinocytes with genomic and antigenomic HCV-RNA, respectively ) than in LP lesions (31.7 ± 7.9% and 18.8 ± 7.4%) or healthy adjacent skin (24.8 ± 6.9% and 14.3 ± 3.8%). In conclusion, in this study we have demonstrated that HCV infects and replicates in keratinocytes from patients with and without LP lesions. On the other hand, the percentage of HCV-infected keratinocytes in patients with chronic hepatitis C was significantly higher in patients with cutaneous LP than in patients with healthy skin. This finding suggests that HCV infection of keratinocytes is involved in the etiopathogenesis of cutaneous LP in patients with HCV infection; however, more studies are required to confirm this hypothesis." @default.
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- W2342149722 date "2004-01-01" @default.
- W2342149722 modified "2023-09-26" @default.
- W2342149722 title "Replicación del virus de la hepatitis C en lesiones cutáneas de liquen plano Hepatitis C virus replication in lichen planus lesions" @default.
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