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• W2342170674 abstract "Synthetic biology provides an opportunity for the construction and exploration of alternative solutions to biological problems - solutions different from those chosen by natural life. To this end, synthetic biologists have built new sensory systems, cellular memories, and alternative genetic codes. There is a growing interest in applying synthetic approaches to multicellular systems, especially in relation to multicellular self-organization. Here we describe a synthetic biological system that confers large-scale de novo patterning activity on 2-D and 3-D populations of mammalian cells. Instead of using the reaction-diffusion mechanisms common in real embryos, our system uses cadherin-mediated phase separation, inspired by the known phenomenon of cadherin-based sorting. An engineered self-organizing, large-scale patterning system requiring no prior spatial cue may be a significant step towards the construction of self-assembling synthetic tissues." @default.
• W2342170674 created "2016-06-24" @default.
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• W2342170674 date "2016-02-09" @default.
• W2342170674 modified "2023-10-14" @default.
• W2342170674 title "2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation" @default.
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• W2342170674 doi "https://doi.org/10.1038/srep20664" @default.
• W2342170674 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4746622" @default.
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