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- W2342173545 abstract "Pancreatic neuroendocrine tumours are heterogeneous malignancies. Surgery maintains a key role within a multimodal approach. Aggressive surgery has risks of major complications and competes in the choice among the available treatments. We investigated the role of surgical complications on recurrence and long term survival after resection at a ENETS Centre of Excellence. We have retrospectively analysed the database of 105 resections from 1998 to 2014, including pre- and postoperative variables from 16 extended pancreatectomies and 13 synchronous liver resections, by uni-multivariate analysis of predictors. WHO 2010 stage was I in 62, II in 35 and III in 8 cases. Stage ENETS was local in 30, locally advanced in 54 and metastatic in 17. Complications presented in 43 patients, required intervention in 19 and surgery in 1. There were 25 pancreatic fistulas, 14 B or C grades. After a 10 days median length of stay (3–85), 34 patients developed exocrine insufficiency, 31 diabetes. 30 cases recurred at a median of 11.7 (0.8–141.5) months. Actuarial disease free survival was 44% at 5 years. Seven patients died, at a median of 28 (0–175) months, 5 of disease recurrence. Actuarial overall survival was 90.1% at 5 years. After univariate analysis high grade pancreatic fistulas and complications were associated with shorter survival (p = 0.021) but not with increased recurrence rate (p = 0.744). At multivariate analysis no predictor was survival-significant. Surgery in pancreatic neuroendocrine tumours should be performed in specialised centres with multimodal approach, where postoperative complications do not affect recurrence rate, disease-free or overall survival." @default.
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- W2342173545 date "2016-04-01" @default.
- W2342173545 modified "2023-10-17" @default.
- W2342173545 title "Postoperative complications do not influence recurrence and long-term survival in surgical resections for pancreatic neuroendocrine tumours" @default.
- W2342173545 doi "https://doi.org/10.1016/j.hpb.2016.03.065" @default.
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