FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342182890> ?p ?o ?g. }

• W2342182890 endingPage "8" @default.
• W2342182890 startingPage "1715" @default.
• W2342182890 abstract "Cytokines are involved in the pathogenesis of different gynecological malignancies. Additionally, they stimulate the spread of cancer cells. Interleukin 10 (IL-10) was described as a pro-inflammatory factor and seems to be implicated in the immune deficiency of patients with cancer. The aim of this study was to determine whether the level of IL-10 in the serum and ascites was associated with the prognosis of advanced ovarian cancer (OC).In a prospective study from 2001 to 2003, the concentration of IL-10 in the serum and ascites of 117 consecutive patients with advanced OC and 30 women with benign disease who underwent surgery as a control group (CG), was analyzed by the enzyme-linked immunosorbent assay. For statistical analyses, the Chi-square test by Pearson, Fisher's exact test and the Mann-Whitney test were employed.The concentrations of IL-10 were a median of 9.87 pg/ml (range 7.8 to 500 pg/ml) in the serum and a median of 43.70 pg/ml (range 7.8 to 389.4 pg/ml) in the ascites of the OC patients. The IL-10 level in the sera of the CG was a median of 7.80 pg/ml (range 7.8 to 62.8 pg/ml) and 18.34 pg/ml (range 7.8 to 88.72 pg/ml) in the peritoneal fluid. A significant association was observed between the IL-10 serum levels (p = 0.003) and levels in the peritoneal fluid (p = 0.03) in both OC and the CG. IL-10 was significantly more expressed in the ascites of patients with OC than in their sera (p = 0.003). The concentration of IL-10 correlated significantly with proven conventional prognostic factors such as recurrence status (p = 0.005), volume of (ascites, p < 0.001, serum, p = 0.03), histological grading (p = 0.053) and histological type (ascites p = 0.005/ serum p = 0.09). There was no significant correlation between the levels of lL-10 in the ascites and/or serum and FIGO stage, residual tumor mass or age. The cut-off value of 8.0 pg/ml for IL-10 serum levels had a positive predictive value of 84% (95% CI: 76-91) and a negative predictive value of 29% (95% CI: 16-41), with a specificity and sensibility of 47% (95% CI: 29-65) and 70% (95% CI: 62-78), respectively.Due to the fact that the levels of IL-10 were significantly higher in the ascites and serum of OC patients than in those of the CG, IL-10 may play an important immunosuppressive role in the pathogenesis of OC. The association between high IL-10 levels in ascites and serum and the histological type of the tumor, as well as between the levels in the peritoneal cavity and grading, suggest that IL-10 could be a prognostic factor in OC." @default.
• W2342182890 created "2016-06-24" @default.
• W2342182890 creator A5002555374 @default.
• W2342182890 creator A5016734276 @default.
• W2342182890 creator A5025866147 @default.
• W2342182890 creator A5032677101 @default.
• W2342182890 creator A5056394671 @default.
• W2342182890 creator A5059327156 @default.
• W2342182890 creator A5088082888 @default.
• W2342182890 creator A5089741753 @default.
• W2342182890 date "2006-04-19" @default.
• W2342182890 modified "2023-10-03" @default.
• W2342182890 title "Expression of IL-10 in patients with ovarian carcinoma." @default.
• W2342182890 cites W1494102420 @default.
• W2342182890 cites W1942879517 @default.
• W2342182890 cites W1947771442 @default.
• W2342182890 cites W1976764902 @default.
• W2342182890 cites W1982738210 @default.
• W2342182890 cites W1987589866 @default.
• W2342182890 cites W2000762690 @default.
• W2342182890 cites W2006492631 @default.
• W2342182890 cites W2012749338 @default.
• W2342182890 cites W2021112267 @default.
• W2342182890 cites W2061782632 @default.
• W2342182890 cites W2074478044 @default.
• W2342182890 cites W2078623687 @default.
• W2342182890 cites W2083765379 @default.
• W2342182890 cites W2094354431 @default.
• W2342182890 cites W2101771134 @default.
• W2342182890 cites W2137745956 @default.
• W2342182890 cites W2138178697 @default.
• W2342182890 cites W2406830682 @default.
• W2342182890 cites W2409276685 @default.
• W2342182890 cites W2467878591 @default.
• W2342182890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16617566" @default.
• W2342182890 hasPublicationYear "2006" @default.
• W2342182890 type Work @default.
• W2342182890 sameAs 2342182890 @default.
• W2342182890 citedByCount "22" @default.
• W2342182890 countsByYear W23421828902012 @default.
• W2342182890 countsByYear W23421828902015 @default.
• W2342182890 countsByYear W23421828902016 @default.
• W2342182890 countsByYear W23421828902017 @default.
• W2342182890 countsByYear W23421828902018 @default.
• W2342182890 countsByYear W23421828902019 @default.
• W2342182890 countsByYear W23421828902022 @default.
• W2342182890 countsByYear W23421828902023 @default.
• W2342182890 crossrefType "journal-article" @default.
• W2342182890 hasAuthorship W2342182890A5002555374 @default.
• W2342182890 hasAuthorship W2342182890A5016734276 @default.
• W2342182890 hasAuthorship W2342182890A5025866147 @default.
• W2342182890 hasAuthorship W2342182890A5032677101 @default.
• W2342182890 hasAuthorship W2342182890A5056394671 @default.
• W2342182890 hasAuthorship W2342182890A5059327156 @default.
• W2342182890 hasAuthorship W2342182890A5088082888 @default.
• W2342182890 hasAuthorship W2342182890A5089741753 @default.
• W2342182890 hasConcept C121608353 @default.
• W2342182890 hasConcept C126322002 @default.
• W2342182890 hasConcept C12868164 @default.
• W2342182890 hasConcept C188816634 @default.
• W2342182890 hasConcept C191093355 @default.
• W2342182890 hasConcept C2777546739 @default.
• W2342182890 hasConcept C2780427987 @default.
• W2342182890 hasConcept C2780496750 @default.
• W2342182890 hasConcept C2780942790 @default.
• W2342182890 hasConcept C29456083 @default.
• W2342182890 hasConcept C3019054536 @default.
• W2342182890 hasConcept C71924100 @default.
• W2342182890 hasConcept C90924648 @default.
• W2342182890 hasConcept C98055416 @default.
• W2342182890 hasConceptScore W2342182890C121608353 @default.
• W2342182890 hasConceptScore W2342182890C126322002 @default.
• W2342182890 hasConceptScore W2342182890C12868164 @default.
• W2342182890 hasConceptScore W2342182890C188816634 @default.
• W2342182890 hasConceptScore W2342182890C191093355 @default.
• W2342182890 hasConceptScore W2342182890C2777546739 @default.
• W2342182890 hasConceptScore W2342182890C2780427987 @default.
• W2342182890 hasConceptScore W2342182890C2780496750 @default.
• W2342182890 hasConceptScore W2342182890C2780942790 @default.
• W2342182890 hasConceptScore W2342182890C29456083 @default.
• W2342182890 hasConceptScore W2342182890C3019054536 @default.
• W2342182890 hasConceptScore W2342182890C71924100 @default.
• W2342182890 hasConceptScore W2342182890C90924648 @default.
• W2342182890 hasConceptScore W2342182890C98055416 @default.
• W2342182890 hasIssue "2C" @default.
• W2342182890 hasLocation W23421828901 @default.
• W2342182890 hasOpenAccess W2342182890 @default.
• W2342182890 hasPrimaryLocation W23421828901 @default.
• W2342182890 hasRelatedWork W2013264198 @default.
• W2342182890 hasRelatedWork W2023414566 @default.
• W2342182890 hasRelatedWork W2070891268 @default.
• W2342182890 hasRelatedWork W2116586212 @default.
• W2342182890 hasRelatedWork W2123579537 @default.
• W2342182890 hasRelatedWork W2189039934 @default.
• W2342182890 hasRelatedWork W2342182890 @default.
• W2342182890 hasRelatedWork W2418988163 @default.
• W2342182890 hasRelatedWork W2430603612 @default.
• W2342182890 hasRelatedWork W4200556486 @default.

• next