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- W2342193130 abstract "ABSTRACT Isolated hearts of Helix pomatia could be maintained for 3–4 days at 19 °C in physiological saline. Co-ordination was soon lost, but irregular twitches could be observed for up to 115 h. A perfusion apparatus was designed which supplied a simulated venous return pressure of 8 cm saline and enabled in vitro survival of pericardium-free hearts for up to 2 days at 15 °C. Cessation of perfusion led immediately to a reversible stoppage of heart-beat. An artificial pericardium apparatus (APA) allowed the role of the pericardium to be studied. In the APA measurable translocation of fluid was effected by the heart, even when the simulated venous return pressure was negative. If the APA was transformed into an open system by opening up a simulated reno-pericardial canal, the effectiveness of the heart was greatly reduced. In the APA the greater the dilation of the heart (in consequence of decreased volume of pericardial fluid) the greater was the stroke volume for a given simulated venous return pressure. Results obtained with the APA give support to the theory that in the gastropod heart the filling of the auricle is hydrodynamically coupled (through the pericardial fluid) to the emptying of the ventricle." @default.
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- W2342193130 date "1972-02-01" @default.
- W2342193130 modified "2023-09-29" @default.
- W2342193130 title "Experiments with the Isolated Heart of the Gastropod <i>Helix Pomatia</i> in an Artificial Pericardium" @default.
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- W2342193130 doi "https://doi.org/10.1242/jeb.56.1.239" @default.
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