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- W2342202389 abstract "Exosomesaremembranevesiclesthatarereleasedbycellsuponfusionofmultivesicularbodies with the plasma membrane. Their molecular composition reflects their originin endosomes as intraluminal vesicles. In addition to a common set of membrane andcytosolic molecules, exosomes harbor unique subsets of proteins linked to cell type–associatedfunctions.Exosomesecretion participatesintheeradicationofobsoletepro-teins but several findings, essentially in the immune system, indicate that exosomesconstitute a potential mode of intercellular communication. Release of exosomes bytumor cells and their implication in the propagation of unconventional pathogenssuch as prions suggests their participation in pathological situations. These findingsopen up new therapeutic and diagnostic strategies.Key words: ESCRT machinery, exosomes, multivesicular bodies (MVBs),intercellular communication, ransmissible pathogens." @default.
- W2342202389 created "2016-06-24" @default.
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- W2342202389 date "2006-01-01" @default.
- W2342202389 modified "2023-09-27" @default.
- W2342202389 title "JB Minireview—Membrane Traffic in Physiology and Pathology Exosomes: A Common Pathway for a Specialized Function" @default.
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