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• W2342211743 endingPage "55" @default.
• W2342211743 startingPage "31" @default.
• W2342211743 abstract "Proteins are frequently modified by complex carbohydrates (glycans) that play central roles in maintaining the structural and functional integrity of cells and tissues in humans and lower organisms. Mannose forms an essential building block of protein glycosylation, and its functional involvement as components of larger and diverse α-mannosidic glycoepitopes in important intra- and intercellular glycoimmunological processes is gaining recognition. With a focus on the mannose-rich asparagine (N-linked) glycosylation type, this review summarises the increasing volume of literature covering human and non-human protein mannosylation, including their structures, biosynthesis and spatiotemporal expression. The review also covers their known interactions with specialised host and microbial mannose-recognising C-type lectin receptors (mrCLRs) and antibodies (mrAbs) during inflammation and pathogen infection. Advances in molecular mapping technologies have recently revealed novel immuno-centric mannose-terminating truncated N-glycans, termed paucimannosylation, on human proteins. The cellular presentation of α-mannosidic glycoepitopes on N-glycoproteins appears tightly regulated; α-mannose determinants are relative rare glycoepitopes in physiological extracellular environments, but may be actively secreted or leaked from cells to transmit potent signals when required. Simultaneously, our understanding of the molecular basis on the recognition of mannosidic epitopes by mrCLRs including DC-SIGN, mannose receptor, mannose binding lectin and mrAb is rapidly advancing, together with the functional implications of these interactions in facilitating an effective immune response during physiological and pathophysiological conditions. Ultimately, deciphering these complex mannose-based receptor–ligand interactions at the detailed molecular level will significantly advance our understanding of immunological disorders and infectious diseases, promoting the development of future therapeutics to improve patient clinical outcomes." @default.
• W2342211743 created "2016-06-24" @default.
• W2342211743 creator A5018317721 @default.
• W2342211743 creator A5037819491 @default.
• W2342211743 creator A5043680660 @default.
• W2342211743 creator A5090521668 @default.
• W2342211743 date "2016-10-01" @default.
• W2342211743 modified "2023-10-16" @default.
• W2342211743 title "Emerging roles of protein mannosylation in inflammation and infection" @default.
• W2342211743 cites W1182461782 @default.
• W2342211743 cites W1483239677 @default.
• W2342211743 cites W1495488294 @default.
• W2342211743 cites W1507609158 @default.
• W2342211743 cites W1513650367 @default.
• W2342211743 cites W1524034741 @default.
• W2342211743 cites W1540808432 @default.
• W2342211743 cites W1542144185 @default.
• W2342211743 cites W1563750046 @default.
• W2342211743 cites W1604992114 @default.
• W2342211743 cites W1691646448 @default.
• W2342211743 cites W1767274962 @default.
• W2342211743 cites W1779052524 @default.
• W2342211743 cites W1795743320 @default.
• W2342211743 cites W1796017043 @default.
• W2342211743 cites W1850336480 @default.
• W2342211743 cites W1855660003 @default.
• W2342211743 cites W1873664205 @default.
• W2342211743 cites W1889757428 @default.
• W2342211743 cites W1895125947 @default.
• W2342211743 cites W1926410203 @default.
• W2342211743 cites W192731551 @default.
• W2342211743 cites W1952097885 @default.
• W2342211743 cites W1963521654 @default.
• W2342211743 cites W1964092171 @default.
• W2342211743 cites W1964113011 @default.
• W2342211743 cites W1965313627 @default.
• W2342211743 cites W1966564771 @default.
• W2342211743 cites W1966925604 @default.
• W2342211743 cites W1967126372 @default.
• W2342211743 cites W1968155668 @default.
• W2342211743 cites W1969267175 @default.
• W2342211743 cites W1971152739 @default.
• W2342211743 cites W1971316228 @default.
• W2342211743 cites W1971907885 @default.
• W2342211743 cites W1972375269 @default.
• W2342211743 cites W1973238005 @default.
• W2342211743 cites W1973719870 @default.
• W2342211743 cites W1975456619 @default.
• W2342211743 cites W1977432663 @default.
• W2342211743 cites W1978351897 @default.
• W2342211743 cites W1979050735 @default.
• W2342211743 cites W1982157821 @default.
• W2342211743 cites W1983161997 @default.
• W2342211743 cites W1984000875 @default.
• W2342211743 cites W1984378291 @default.
• W2342211743 cites W1984567902 @default.
• W2342211743 cites W1984716857 @default.
• W2342211743 cites W1985674001 @default.
• W2342211743 cites W1986366561 @default.
• W2342211743 cites W1987194292 @default.
• W2342211743 cites W1987217273 @default.
• W2342211743 cites W1987273335 @default.
• W2342211743 cites W1987313116 @default.
• W2342211743 cites W1988386668 @default.
• W2342211743 cites W1988536357 @default.
• W2342211743 cites W1988639805 @default.
• W2342211743 cites W1988755416 @default.
• W2342211743 cites W1989947263 @default.
• W2342211743 cites W1991795415 @default.
• W2342211743 cites W1992939453 @default.
• W2342211743 cites W1994089342 @default.
• W2342211743 cites W1994245422 @default.
• W2342211743 cites W1995062416 @default.
• W2342211743 cites W1995191746 @default.
• W2342211743 cites W1995969712 @default.
• W2342211743 cites W1996242613 @default.
• W2342211743 cites W1997045271 @default.
• W2342211743 cites W1997526157 @default.
• W2342211743 cites W2000475809 @default.
• W2342211743 cites W2000831686 @default.
• W2342211743 cites W2000938340 @default.
• W2342211743 cites W2002803179 @default.
• W2342211743 cites W2004638361 @default.
• W2342211743 cites W2005183346 @default.
• W2342211743 cites W2007058937 @default.
• W2342211743 cites W2007191235 @default.
• W2342211743 cites W2007476453 @default.
• W2342211743 cites W2007589323 @default.
• W2342211743 cites W2008854460 @default.
• W2342211743 cites W2009117616 @default.
• W2342211743 cites W2009296003 @default.
• W2342211743 cites W2010980655 @default.
• W2342211743 cites W2012601520 @default.
• W2342211743 cites W2012657759 @default.
• W2342211743 cites W2012804478 @default.
• W2342211743 cites W2012904769 @default.
• W2342211743 cites W2013236045 @default.
• W2342211743 cites W2013845401 @default.

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