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- W2342235799 abstract "Although several previous studies have been published on the effects of dipeptidase-4 (DPP-4) inhibitors in diabetic hemodialysis (HD) patients, the findings have yet to be reviewed comprehensively. Eyesight failure caused by diabetic retinopathy and aging-related dementia make multiple daily insulin injections difficult for HD patients. Therefore, we reviewed the effects of DPP-4 inhibitors with a focus on oral antidiabetic drugs as a new treatment strategy in HD patients with diabetes. The following 7 DPP-4 inhibitors are available worldwide: sitagliptin, vildagliptin, alogliptin, linagliptin, teneligliptin, anagliptin, and saxagliptin. All of these are administered once daily with dose adjustments in HD patients. Four types of oral antidiabetic drugs can be administered for combination oral therapy with DPP-4 inhibitors, including sulfonylureas, meglitinide, thiazolidinediones, and alpha-glucosidase inhibitor. Nine studies examined the antidiabetic effects in HD patients. Treatments decreased hemoglobin A1c and glycated albumin levels by 0.3% to 1.3% and 1.7% to 4.9%, respectively. The efficacy of DPP-4 inhibitor treatment is high among HD patients, and no patients exhibited significant severe adverse effects such as hypoglycemia and liver dysfunction. DPP-4 inhibitors are key drugs in new treatment strategies for HD patients with diabetes and with limited choices for diabetes treatment." @default.
- W2342235799 created "2016-06-24" @default.
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- W2342235799 date "2015-01-01" @default.
- W2342235799 modified "2023-10-18" @default.
- W2342235799 title "Diabetes therapies in hemodialysis patients: Dipeptidase-4 inhibitors" @default.
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- W2342235799 doi "https://doi.org/10.4239/wjd.v6.i6.840" @default.
- W2342235799 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4478579" @default.
- W2342235799 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26131325" @default.
- W2342235799 hasPublicationYear "2015" @default.
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