Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342283054> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2342283054 endingPage "1376" @default.
- W2342283054 startingPage "1369" @default.
- W2342283054 abstract "A sensitive and specific blood test for cancer has long been sought. The water-suppressed proton nuclear magnetic resonance (NMR) spectrum of plasma is dominated by the resonances of plasma lipoprotein lipids. We measured the mean line widths of the methyl and methylene resonances, which were found to be correlated with the presence or absence of malignant tumors. Values for the average line width were lower in patients with cancer. We analyzed plasma from 331 people (normal controls, patients with malignant and benign tumors, patients without tumors, and pregnant patients); NMR analysis and measurement of line widths were blinded to diagnosis or patient group. The mean line width for 44 normal controls (+/- SD) was 39.5 +/- 1.6 Hz. For 81 patients with untreated cancer, demonstrated by biopsy, the line width was 29.9 +/- 2.5 Hz. Patients with malignant tumors were reliably distinguished from normal controls by this method (P less than 0.0001), and differed from patients with diseases that did not involve tumors (line width, 36.1 +/- 2.6 Hz; P less than 0.0001). Patients with benign tumors (e.g., those of the breast, ovary, uterus, and colon) had line widths of 36.7 +/- 2.0 Hz and were different from those with malignant tumors (P less than 0.0001). However, pregnant patients and those with benign prostatic hyperplasia had line widths consistent with the presence of malignant tumors. The narrowing of lipoprotein-lipid resonances with cancer is consistent with the response of a host to tumor growth. We conclude that these preliminary results demonstrate that water-suppressed proton NMR spectroscopy is a potentially valuable approach to the detection of cancer and the monitoring of therapy." @default.
- W2342283054 created "2016-06-24" @default.
- W2342283054 creator A5033747347 @default.
- W2342283054 creator A5051552056 @default.
- W2342283054 creator A5068418667 @default.
- W2342283054 date "1986-11-27" @default.
- W2342283054 modified "2023-10-03" @default.
- W2342283054 title "Detection of Malignant Tumors" @default.
- W2342283054 cites W1972686807 @default.
- W2342283054 cites W1981019867 @default.
- W2342283054 cites W2002209097 @default.
- W2342283054 cites W2004341554 @default.
- W2342283054 cites W2053707554 @default.
- W2342283054 cites W2055782762 @default.
- W2342283054 cites W2059290379 @default.
- W2342283054 cites W2061514716 @default.
- W2342283054 cites W2079241619 @default.
- W2342283054 cites W2080942987 @default.
- W2342283054 cites W2083318548 @default.
- W2342283054 cites W2086807063 @default.
- W2342283054 cites W2086995138 @default.
- W2342283054 cites W2088926580 @default.
- W2342283054 cites W2207853819 @default.
- W2342283054 cites W2273598842 @default.
- W2342283054 cites W2397462862 @default.
- W2342283054 cites W2402328594 @default.
- W2342283054 doi "https://doi.org/10.1056/nejm198611273152201" @default.
- W2342283054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3022146" @default.
- W2342283054 hasPublicationYear "1986" @default.
- W2342283054 type Work @default.
- W2342283054 sameAs 2342283054 @default.
- W2342283054 citedByCount "184" @default.
- W2342283054 countsByYear W23422830542012 @default.
- W2342283054 countsByYear W23422830542013 @default.
- W2342283054 countsByYear W23422830542014 @default.
- W2342283054 countsByYear W23422830542016 @default.
- W2342283054 countsByYear W23422830542017 @default.
- W2342283054 countsByYear W23422830542018 @default.
- W2342283054 countsByYear W23422830542019 @default.
- W2342283054 countsByYear W23422830542022 @default.
- W2342283054 crossrefType "journal-article" @default.
- W2342283054 hasAuthorship W2342283054A5033747347 @default.
- W2342283054 hasAuthorship W2342283054A5051552056 @default.
- W2342283054 hasAuthorship W2342283054A5068418667 @default.
- W2342283054 hasConcept C121608353 @default.
- W2342283054 hasConcept C126322002 @default.
- W2342283054 hasConcept C126838900 @default.
- W2342283054 hasConcept C142724271 @default.
- W2342283054 hasConcept C143409427 @default.
- W2342283054 hasConcept C2775934546 @default.
- W2342283054 hasConcept C2778324911 @default.
- W2342283054 hasConcept C2989005 @default.
- W2342283054 hasConcept C530470458 @default.
- W2342283054 hasConcept C71924100 @default.
- W2342283054 hasConcept C90924648 @default.
- W2342283054 hasConceptScore W2342283054C121608353 @default.
- W2342283054 hasConceptScore W2342283054C126322002 @default.
- W2342283054 hasConceptScore W2342283054C126838900 @default.
- W2342283054 hasConceptScore W2342283054C142724271 @default.
- W2342283054 hasConceptScore W2342283054C143409427 @default.
- W2342283054 hasConceptScore W2342283054C2775934546 @default.
- W2342283054 hasConceptScore W2342283054C2778324911 @default.
- W2342283054 hasConceptScore W2342283054C2989005 @default.
- W2342283054 hasConceptScore W2342283054C530470458 @default.
- W2342283054 hasConceptScore W2342283054C71924100 @default.
- W2342283054 hasConceptScore W2342283054C90924648 @default.
- W2342283054 hasIssue "22" @default.
- W2342283054 hasLocation W23422830541 @default.
- W2342283054 hasLocation W23422830542 @default.
- W2342283054 hasOpenAccess W2342283054 @default.
- W2342283054 hasPrimaryLocation W23422830541 @default.
- W2342283054 hasRelatedWork W2014447844 @default.
- W2342283054 hasRelatedWork W2052739710 @default.
- W2342283054 hasRelatedWork W2102164644 @default.
- W2342283054 hasRelatedWork W2297592050 @default.
- W2342283054 hasRelatedWork W2514715810 @default.
- W2342283054 hasRelatedWork W3029022581 @default.
- W2342283054 hasRelatedWork W3130591221 @default.
- W2342283054 hasRelatedWork W3196332669 @default.
- W2342283054 hasRelatedWork W4313490384 @default.
- W2342283054 hasRelatedWork W4365129602 @default.
- W2342283054 hasVolume "315" @default.
- W2342283054 isParatext "false" @default.
- W2342283054 isRetracted "false" @default.
- W2342283054 magId "2342283054" @default.
- W2342283054 workType "article" @default.