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• W2342316560 abstract "WDR92 is a highly conserved WD-repeat protein that has been proposed to be involved in apoptosis and also to be part of a prefoldin-like cochaperone complex. We found that WDR92 has a phylogenetic signature that is generally compatible with it playing a role in the assembly or function of specifically motile cilia. To test this hypothesis, we performed an RNAi-based knockdown of WDR92 gene expression in the planarian Schmidtea mediterranea and were able to achieve a robust reduction in mRNA expression to levels undetectable under our standard RT-PCR conditions. We found that this treatment resulted in a dramatic reduction in the rate of organismal movement that was caused by a switch in the mode of locomotion from smooth, cilia-driven gliding to muscle-based, peristaltic contractions. Although the knockdown animals still assembled cilia of normal length and in similar numbers to controls, these structures had reduced beat frequency and did not maintain hydrodynamic coupling. By transmission electron microscopy we observed that many cilia had pleiomorphic defects in their architecture, including partial loss of dynein arms, incomplete closure of the B-tubule, and occlusion or replacement of the central pair complex by accumulated electron-dense material. These observations suggest that WDR92 is part of a previously unrecognized cytoplasmic chaperone system that is specifically required to fold key components necessary to build motile ciliary axonemes." @default.
• W2342316560 created "2016-06-24" @default.
• W2342316560 creator A5044354794 @default.
• W2342316560 creator A5055254748 @default.
• W2342316560 date "2016-04-15" @default.
• W2342316560 modified "2023-09-30" @default.
• W2342316560 title "A prefoldin-associated WD-repeat protein (WDR92) is required for the correct architectural assembly of motile cilia" @default.
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• W2342316560 doi "https://doi.org/10.1091/mbc.e16-01-0040" @default.
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