FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342398977> ?p ?o ?g. }

• W2342398977 abstract "Abstract Leukemia cells exhibit alterations in intermediary metabolism similar to other cancers, wherein ATP sourcing is shunted from mitochondrial oxphos towards glycolytic preponderance (Warburg Effect) to meet oncogenic proliferative demands. A consequence of this metabolic switch is the simultaneous short-circuit of the programmed death pathways, leading to a immortalization program in cancer cells including leukemia. Delivery of high levels of CoQ10 in a lipid nanodispersion mixture (BPM31510) has been demonstrated to preferentially shift metabolic networks from glycolysis towards mitochondrial-centric oxphos and recapitulation of apoptotic pathways in various cancers in vitro and in vivo models. Given the centrality of the Bcl-2 involvement in the etiology of leukemia, this study focused on investigation of the effectiveness of BPM31510 in animal models of erythroid and myeloid leukemia. Human acute erythro-leukemia (K562) and acute myeloid leukemia (KG1) models were developed in immune-compromised mice. The mice (total n=120 for each model respectively) were randomized into four (n=30/group) treatment groups: Untreated (control); BPM31510 (75 mg/kg, once/day); chemotherapy (Adriamycin [5mg/kg; once/wk]+AraC [25mg/kg; 5 days] and BPM31510+chemotherapy. All dosing were intravenous and followed a protocol of 3wk treatment followed by 1wk rest. In both leukemia models, combination of BPM31510 with chemotherapy was associated with significant increase in survival compared to other groups. BPM31510 alone improved survival compared to chemotherapy in myeloid leukemia, not in erythroleukemia model. In a separate study, a rat (Fisher 344) chloroleukemia (MIA C51) model of CNS leukemia was developed that demonstrated paraplegia and urinary retention as a result of brain metastasis. Administration of BPM31510 (50 mg/kg/day, IP) was associated with complete resolution of limb paralysis demonstrating the ability of BPM31510 in penetrating into the CNS. Moreover, BPM31510 (50 mg/kg/day, IP) administration was associated with significant increase in survival in animals with metastasis to the lungs and liver. The data provides encouraging evidence of the potential translational use of CoQ10 containing BPM31510 in the treatment of leukemia. A Phase 1 study in relapse acute leukemia is to be started shortly. Disclosures: Narain: Berg: Employment. Akmaev:Berg: Employment. Benaim:Berg: Employment. Sarangarajan:Berg: Employment. Jimenez:Berg: Membership on an entity’s Board of Directors or advisory committees." @default.
• W2342398977 created "2016-06-24" @default.
• W2342398977 creator A5032034522 @default.
• W2342398977 creator A5033961935 @default.
• W2342398977 creator A5058081424 @default.
• W2342398977 creator A5068009659 @default.
• W2342398977 creator A5074830972 @default.
• W2342398977 creator A5088280452 @default.
• W2342398977 date "2013-11-15" @default.
• W2342398977 modified "2023-09-28" @default.
• W2342398977 title "Parenteral CoQ10 Formulation (BPM31510) Significantly Improves Survival In Animal Model Of Leukemia Including The Resolution Of Paraplegia Due To Brain Metastasis" @default.
• W2342398977 doi "https://doi.org/10.1182/blood.v122.21.1457.1457" @default.
• W2342398977 hasPublicationYear "2013" @default.
• W2342398977 type Work @default.
• W2342398977 sameAs 2342398977 @default.
• W2342398977 citedByCount "0" @default.
• W2342398977 crossrefType "journal-article" @default.
• W2342398977 hasAuthorship W2342398977A5032034522 @default.
• W2342398977 hasAuthorship W2342398977A5033961935 @default.
• W2342398977 hasAuthorship W2342398977A5058081424 @default.
• W2342398977 hasAuthorship W2342398977A5068009659 @default.
• W2342398977 hasAuthorship W2342398977A5074830972 @default.
• W2342398977 hasAuthorship W2342398977A5088280452 @default.
• W2342398977 hasConcept C121608353 @default.
• W2342398977 hasConcept C126322002 @default.
• W2342398977 hasConcept C203014093 @default.
• W2342398977 hasConcept C2776694085 @default.
• W2342398977 hasConcept C2778461978 @default.
• W2342398977 hasConcept C2778729363 @default.
• W2342398977 hasConcept C2779282312 @default.
• W2342398977 hasConcept C502942594 @default.
• W2342398977 hasConcept C71924100 @default.
• W2342398977 hasConcept C86803240 @default.
• W2342398977 hasConceptScore W2342398977C121608353 @default.
• W2342398977 hasConceptScore W2342398977C126322002 @default.
• W2342398977 hasConceptScore W2342398977C203014093 @default.
• W2342398977 hasConceptScore W2342398977C2776694085 @default.
• W2342398977 hasConceptScore W2342398977C2778461978 @default.
• W2342398977 hasConceptScore W2342398977C2778729363 @default.
• W2342398977 hasConceptScore W2342398977C2779282312 @default.
• W2342398977 hasConceptScore W2342398977C502942594 @default.
• W2342398977 hasConceptScore W2342398977C71924100 @default.
• W2342398977 hasConceptScore W2342398977C86803240 @default.
• W2342398977 hasLocation W23423989771 @default.
• W2342398977 hasOpenAccess W2342398977 @default.
• W2342398977 hasPrimaryLocation W23423989771 @default.
• W2342398977 hasRelatedWork W1081989139 @default.
• W2342398977 hasRelatedWork W110923738 @default.
• W2342398977 hasRelatedWork W1839937968 @default.
• W2342398977 hasRelatedWork W192468570 @default.
• W2342398977 hasRelatedWork W1973579335 @default.
• W2342398977 hasRelatedWork W1978969587 @default.
• W2342398977 hasRelatedWork W1980286337 @default.
• W2342398977 hasRelatedWork W2024731052 @default.
• W2342398977 hasRelatedWork W2061201927 @default.
• W2342398977 hasRelatedWork W2088851414 @default.
• W2342398977 hasRelatedWork W2113231065 @default.
• W2342398977 hasRelatedWork W2113454779 @default.
• W2342398977 hasRelatedWork W2128559106 @default.
• W2342398977 hasRelatedWork W2148320270 @default.
• W2342398977 hasRelatedWork W2329711020 @default.
• W2342398977 hasRelatedWork W2408627149 @default.
• W2342398977 hasRelatedWork W2586292908 @default.
• W2342398977 hasRelatedWork W2604573493 @default.
• W2342398977 hasRelatedWork W2985838501 @default.
• W2342398977 hasRelatedWork W3147220350 @default.
• W2342398977 isParatext "false" @default.
• W2342398977 isRetracted "false" @default.
• W2342398977 magId "2342398977" @default.
• W2342398977 workType "article" @default.