Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342425781> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2342425781 endingPage "53" @default.
- W2342425781 startingPage "53" @default.
- W2342425781 abstract "The prophylaxis is an important strategy to control of human and animal rabies disease. The vaccine from Vero cellular culture for human use is efficacy and safety. However, because the technology used to produce this vaccine is expensive this product costs about ten dollars. This cost makes them impossible the use of this vaccine type in poor countries where the animal rabies control is inefficient and there many cases of human rabies. Rabies disease is responsible for about 55,000 deaths per year in the world. The objective of this study was evaluate the humoral immune response of mice (Balb/c) immunized with three different doses of Vero rabies vaccine associated with the BpMPLA-SE adjuvant. This adjuvant is a product obtained from Bordetella pertusis. Three groups of ten mice were immunized with two doses of 500μl (G1), 250μl (G2) or 125μl (G3) of Vero cell rabies vaccine (IB-lot 1103075) mixed with BpMPLA-SE (10μg/dose). Three groups control (Gc) received only rabies vaccine. The immunization occurred on days 0 and 21 and samples were taken ten days after the last dose injected and on days 60, 120 and 180 to determine the titers of neutralizing antibodies for rabies virus in BHK21 cells (RFFIT). The averages of the neutralizing antibodies titers found in the samples from each group ten days after finished the immunization were 39.2, 33.1, and 20.4 IU/ml for groups G1, G2 and G3 respectively. The results obtained on day 180 were 17.1 IU /ml (G1), 10.6 IU/ml (G2) and 9.8 (G3). In the control groups the averages of the antibodies titers were: 29.7 (Gc1), 26.9 (Gc2) and 22.2 IU/ml (Gc3) after immunization and 10.7 (Gc1), 9.5 (Gc2) and 8.5 IU/ml (GC3) on day 180 (Gc3). These data show that the adjuvant BpMPLA-SE increased the humoral immune response for rabies vaccine in Balb/c mice independent of the volume of vaccine utilized to immunize the animals. The results found are very important to reduce the number of doses and the volume of Vero cell rabies vaccine utilized in the immunization against rabies." @default.
- W2342425781 created "2016-06-24" @default.
- W2342425781 creator A5005682182 @default.
- W2342425781 creator A5050253665 @default.
- W2342425781 creator A5052266131 @default.
- W2342425781 creator A5059582817 @default.
- W2342425781 creator A5060293328 @default.
- W2342425781 creator A5069878139 @default.
- W2342425781 date "2012-01-01" @default.
- W2342425781 modified "2023-09-26" @default.
- W2342425781 title "Immune response of balb/c mice immunized with vero cell rabies vaccine and bpmpla-se adjuvant" @default.
- W2342425781 hasPublicationYear "2012" @default.
- W2342425781 type Work @default.
- W2342425781 sameAs 2342425781 @default.
- W2342425781 citedByCount "0" @default.
- W2342425781 crossrefType "journal-article" @default.
- W2342425781 hasAuthorship W2342425781A5005682182 @default.
- W2342425781 hasAuthorship W2342425781A5050253665 @default.
- W2342425781 hasAuthorship W2342425781A5052266131 @default.
- W2342425781 hasAuthorship W2342425781A5059582817 @default.
- W2342425781 hasAuthorship W2342425781A5060293328 @default.
- W2342425781 hasAuthorship W2342425781A5069878139 @default.
- W2342425781 hasConcept C109663412 @default.
- W2342425781 hasConcept C159047783 @default.
- W2342425781 hasConcept C203014093 @default.
- W2342425781 hasConcept C22070199 @default.
- W2342425781 hasConcept C2522874641 @default.
- W2342425781 hasConcept C2776849203 @default.
- W2342425781 hasConcept C2777863537 @default.
- W2342425781 hasConcept C2777961786 @default.
- W2342425781 hasConcept C2779261636 @default.
- W2342425781 hasConcept C2780674857 @default.
- W2342425781 hasConcept C2780801004 @default.
- W2342425781 hasConcept C32611913 @default.
- W2342425781 hasConcept C71924100 @default.
- W2342425781 hasConcept C8891405 @default.
- W2342425781 hasConcept C89138240 @default.
- W2342425781 hasConceptScore W2342425781C109663412 @default.
- W2342425781 hasConceptScore W2342425781C159047783 @default.
- W2342425781 hasConceptScore W2342425781C203014093 @default.
- W2342425781 hasConceptScore W2342425781C22070199 @default.
- W2342425781 hasConceptScore W2342425781C2522874641 @default.
- W2342425781 hasConceptScore W2342425781C2776849203 @default.
- W2342425781 hasConceptScore W2342425781C2777863537 @default.
- W2342425781 hasConceptScore W2342425781C2777961786 @default.
- W2342425781 hasConceptScore W2342425781C2779261636 @default.
- W2342425781 hasConceptScore W2342425781C2780674857 @default.
- W2342425781 hasConceptScore W2342425781C2780801004 @default.
- W2342425781 hasConceptScore W2342425781C32611913 @default.
- W2342425781 hasConceptScore W2342425781C71924100 @default.
- W2342425781 hasConceptScore W2342425781C8891405 @default.
- W2342425781 hasConceptScore W2342425781C89138240 @default.
- W2342425781 hasLocation W23424257811 @default.
- W2342425781 hasOpenAccess W2342425781 @default.
- W2342425781 hasPrimaryLocation W23424257811 @default.
- W2342425781 hasRelatedWork W1557935818 @default.
- W2342425781 hasRelatedWork W2014043927 @default.
- W2342425781 hasRelatedWork W2040056825 @default.
- W2342425781 hasRelatedWork W2051480153 @default.
- W2342425781 hasRelatedWork W2084184663 @default.
- W2342425781 hasRelatedWork W2105315162 @default.
- W2342425781 hasRelatedWork W2123156812 @default.
- W2342425781 hasRelatedWork W2128489214 @default.
- W2342425781 hasRelatedWork W2150123669 @default.
- W2342425781 hasRelatedWork W2348323180 @default.
- W2342425781 hasRelatedWork W2372337132 @default.
- W2342425781 hasRelatedWork W2376767436 @default.
- W2342425781 hasRelatedWork W2379750004 @default.
- W2342425781 hasRelatedWork W2384404240 @default.
- W2342425781 hasRelatedWork W2387257627 @default.
- W2342425781 hasRelatedWork W2392083638 @default.
- W2342425781 hasRelatedWork W2407163970 @default.
- W2342425781 hasRelatedWork W2436035104 @default.
- W2342425781 hasRelatedWork W3027362807 @default.
- W2342425781 hasRelatedWork W3151006000 @default.
- W2342425781 hasVolume "10" @default.
- W2342425781 isParatext "false" @default.
- W2342425781 isRetracted "false" @default.
- W2342425781 magId "2342425781" @default.
- W2342425781 workType "article" @default.