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- W2342537364 abstract "To study the efficacy and safety of micafungin for prophylaxis of invasive fungal infections in patients undergoing induction chemotherapy for acute myeloid leukemia. A prospective observational single-center study of 41 patients from the hematology department between May 2012 and April 2015. Micafungin was administered once daily from the first day of induction chemotherapy to the end of the neutropenic phase. Neither Candida nor Aspergillus infection was documented in our 41 patients from the first day of micafungin infusion to the end of the neutropenic phase. Patients were followed for three months after discontinuation of micafungin and none of them contracted an invasive fungal infection. Only one patient presented with grade III–IV hepatic and ionic toxicities. Micafungin is associated with a good safety profile and is an interesting option for preventing invasive fungal infections in the high-risk population of patients presenting with hematological disorders. Notre objectif était d’étudier l’efficacité et l’innocuité de la micafungine comme prophylaxie antifongique primaire chez les patients atteints de leucémie aigüe myéloïde. Nous avons inclus 41 patients de mai 2012 à avril 2015. La micafungine a été administrée du premier jour de la chimiothérapie d’induction jusqu’à la fin de la période de neutropénie. Aucune infection à Candida ou Aspergillus n’a été documentée chez nos 41 patients entre le premier jour de la chimiothérapie d’induction et la fin de la période de neutropénie. Trois mois après l’arrêt de la micafungine, aucun patient n’a développé d’infection fongique invasive. Un seul patient a présenté une toxicité de grade III–IV. La micafungine est associée à un excellent profil de tolérance et semble être une option intéressante pour prévenir les infections fongiques invasives dans la population à haut risque des patients traités pour hémopathie maligne." @default.
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- W2342537364 date "2016-06-01" @default.
- W2342537364 modified "2023-09-27" @default.
- W2342537364 title "Micafungin as primary antifungal prophylaxis in patients presenting with acute myeloid leukemia" @default.
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- W2342537364 doi "https://doi.org/10.1016/j.medmal.2016.03.008" @default.
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