FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342547586> ?p ?o ?g. }

• W2342547586 endingPage "C850" @default.
• W2342547586 startingPage "C841" @default.
• W2342547586 abstract "We have studied mitochondrial adaptations in muscle subject to chronic denervation, and their relationship to muscle performance, using a model of unilateral sciatic nerve denervation in rats over periods of 2, 5, 8, 14, 21, 28, 35, and 42 days (n = 5-9 rats/day). Time to peak tension (TPT), one-half relaxation time (1/2RT), and endurance performance were evaluated during in situ stimulation of denervated and contralateral gastrocnemius-plantaris muscles. Denervation led to a 70% decline in muscle mass after 42 days. TPT and 1/2RT increased 17 and 30%, respectively, indicating a transformation toward slower muscle. The activities of the enzymes cytochrome-c oxidase (CYTOX), succinate dehydrogenase, and citrate synthase were decreased by 8-14 days, and by 42 days these were 34-58% of control. The mitochondrial phospholipid cardiolipin was reduced earlier, by 5 days, and gradually decreased to 37% of control. Thus phospholipid removal appears to precede the loss of enzyme activity during decreases in mitochondrial content. Endurance performance was reduced in parallel with decreases in enzyme activity and cardiolipin. Cytochrome c mRNA levels decreased to 52% of control by 5 days. Denervation resulted in coordinated changes in mRNA levels encoding the nuclear-derived CYTOX subunit VIc and the mitochondrially derived CYTOX subunit III. However, changes in CYTOX activity did not always parallel alterations in subunit mRNA levels. Thus transcriptional and translational mechanisms operate in regulating mitochondrial gene expression during denervation." @default.
• W2342547586 created "2016-06-24" @default.
• W2342547586 creator A5035008235 @default.
• W2342547586 creator A5076563879 @default.
• W2342547586 date "1991-04-01" @default.
• W2342547586 modified "2023-10-15" @default.
• W2342547586 title "Mitochondrial adaptations in denervated muscle: relationship to muscle performance" @default.
• W2342547586 cites W1028728095 @default.
• W2342547586 cites W1493283919 @default.
• W2342547586 cites W1521207254 @default.
• W2342547586 cites W1543142265 @default.
• W2342547586 cites W1543342841 @default.
• W2342547586 cites W1555401845 @default.
• W2342547586 cites W1775749144 @default.
• W2342547586 cites W1843570087 @default.
• W2342547586 cites W1990137781 @default.
• W2342547586 cites W2029847466 @default.
• W2342547586 cites W2034905074 @default.
• W2342547586 cites W2036832507 @default.
• W2342547586 cites W2039448295 @default.
• W2342547586 cites W2039869894 @default.
• W2342547586 cites W2046440697 @default.
• W2342547586 cites W2047336443 @default.
• W2342547586 cites W2051240076 @default.
• W2342547586 cites W2061098166 @default.
• W2342547586 cites W2063701650 @default.
• W2342547586 cites W2084500483 @default.
• W2342547586 cites W2129398678 @default.
• W2342547586 cites W2149379499 @default.
• W2342547586 cites W2264398357 @default.
• W2342547586 cites W2298143843 @default.
• W2342547586 cites W2338212990 @default.
• W2342547586 cites W35097411 @default.
• W2342547586 cites W4235883828 @default.
• W2342547586 cites W4255195452 @default.
• W2342547586 doi "https://doi.org/10.1152/ajpcell.1991.260.4.c841" @default.
• W2342547586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1850197" @default.
• W2342547586 hasPublicationYear "1991" @default.
• W2342547586 type Work @default.
• W2342547586 sameAs 2342547586 @default.
• W2342547586 citedByCount "100" @default.
• W2342547586 countsByYear W23425475862012 @default.
• W2342547586 countsByYear W23425475862013 @default.
• W2342547586 countsByYear W23425475862014 @default.
• W2342547586 countsByYear W23425475862015 @default.
• W2342547586 countsByYear W23425475862016 @default.
• W2342547586 countsByYear W23425475862017 @default.
• W2342547586 countsByYear W23425475862018 @default.
• W2342547586 countsByYear W23425475862019 @default.
• W2342547586 countsByYear W23425475862020 @default.
• W2342547586 countsByYear W23425475862021 @default.
• W2342547586 countsByYear W23425475862022 @default.
• W2342547586 countsByYear W23425475862023 @default.
• W2342547586 crossrefType "journal-article" @default.
• W2342547586 hasAuthorship W2342547586A5035008235 @default.
• W2342547586 hasAuthorship W2342547586A5076563879 @default.
• W2342547586 hasConcept C111133373 @default.
• W2342547586 hasConcept C123249941 @default.
• W2342547586 hasConcept C126322002 @default.
• W2342547586 hasConcept C134018914 @default.
• W2342547586 hasConcept C181199279 @default.
• W2342547586 hasConcept C185592680 @default.
• W2342547586 hasConcept C24998067 @default.
• W2342547586 hasConcept C2775872116 @default.
• W2342547586 hasConcept C2776805190 @default.
• W2342547586 hasConcept C2777229759 @default.
• W2342547586 hasConcept C2778918659 @default.
• W2342547586 hasConcept C2779959927 @default.
• W2342547586 hasConcept C2781149210 @default.
• W2342547586 hasConcept C2781302388 @default.
• W2342547586 hasConcept C2781330172 @default.
• W2342547586 hasConcept C28859421 @default.
• W2342547586 hasConcept C41625074 @default.
• W2342547586 hasConcept C55493867 @default.
• W2342547586 hasConcept C71924100 @default.
• W2342547586 hasConcept C86803240 @default.
• W2342547586 hasConceptScore W2342547586C111133373 @default.
• W2342547586 hasConceptScore W2342547586C123249941 @default.
• W2342547586 hasConceptScore W2342547586C126322002 @default.
• W2342547586 hasConceptScore W2342547586C134018914 @default.
• W2342547586 hasConceptScore W2342547586C181199279 @default.
• W2342547586 hasConceptScore W2342547586C185592680 @default.
• W2342547586 hasConceptScore W2342547586C24998067 @default.
• W2342547586 hasConceptScore W2342547586C2775872116 @default.
• W2342547586 hasConceptScore W2342547586C2776805190 @default.
• W2342547586 hasConceptScore W2342547586C2777229759 @default.
• W2342547586 hasConceptScore W2342547586C2778918659 @default.
• W2342547586 hasConceptScore W2342547586C2779959927 @default.
• W2342547586 hasConceptScore W2342547586C2781149210 @default.
• W2342547586 hasConceptScore W2342547586C2781302388 @default.
• W2342547586 hasConceptScore W2342547586C2781330172 @default.
• W2342547586 hasConceptScore W2342547586C28859421 @default.
• W2342547586 hasConceptScore W2342547586C41625074 @default.
• W2342547586 hasConceptScore W2342547586C55493867 @default.
• W2342547586 hasConceptScore W2342547586C71924100 @default.
• W2342547586 hasConceptScore W2342547586C86803240 @default.
• W2342547586 hasIssue "4" @default.
• W2342547586 hasLocation W23425475861 @default.

• next