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• W2342622014 abstract "The movement toward precision medicine for cancer therapy has been hindered by innate and acquired resistance to targeted therapeutics. Common oncogenes and tumor suppressors act in a signaling network that converges on mTORC1, leading to its aberrant activation in the majority of tumors. While mTOR inhibitors are effective as monotherapies in some tumor settings, such as tuberous sclerosis complex, they are generally not sufficient to achieve antitumor responses in most sporadic cancers. Evidence from multiple cancer lineages have demonstrated that sustained mTORC1 signaling following treatment with a targeted therapeutic is strongly associated with both innate and acquired resistance to that drug. There is growing evidence that mTOR inhibitors are effective in combination with other targeted therapeutics to achieve prolonged antitumor responses and delay resistance. The movement toward precision medicine with targeted therapeutics for cancer treatment has been hindered by both innate and acquired resistance. Understanding the molecular wiring and plasticity of oncogenic signaling networks is essential for the development of therapeutic strategies to avoid or overcome resistance. The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) represents a highly integrated signaling node that is dysregulated in the majority of human cancers. Several studies have revealed that sustained mTORC1 inhibition is essential to avoid resistance to therapeutics targeted against the driving oncogenic pathway in a given cancer. We discuss the role of mTORC1 in dictating the response of tumors to targeted therapeutics and review recent examples from lung cancer, breast cancer, and melanoma. The movement toward precision medicine with targeted therapeutics for cancer treatment has been hindered by both innate and acquired resistance. Understanding the molecular wiring and plasticity of oncogenic signaling networks is essential for the development of therapeutic strategies to avoid or overcome resistance. The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) represents a highly integrated signaling node that is dysregulated in the majority of human cancers. Several studies have revealed that sustained mTORC1 inhibition is essential to avoid resistance to therapeutics targeted against the driving oncogenic pathway in a given cancer. We discuss the role of mTORC1 in dictating the response of tumors to targeted therapeutics and review recent examples from lung cancer, breast cancer, and melanoma." @default.
• W2342622014 created "2016-06-24" @default.
• W2342622014 creator A5030272551 @default.
• W2342622014 creator A5070888686 @default.
• W2342622014 date "2016-05-01" @default.
• W2342622014 modified "2023-10-14" @default.
• W2342622014 title "Emerging Role of mTOR in the Response to Cancer Therapeutics" @default.
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