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• W2342701607 abstract "Galectins are a group of animal lectins characterized by their specificity for β-galactosides. Mouse galectin-2 (mGal-2) is predominantly expressed in the gastrointestinal tract and has been identified as one of the main gastric mucosal proteins that are uniquely sensitive to S-nitrosylation. We have previously reported that oxidation of mGal-2 by hydrogen peroxide (H 2 O 2 ) resulted in the loss of sugar-binding ability, whereas pre-treatment of mGal-2 with S-nitrosocysteine prevented H 2 O 2 -induced inactivation. In this study, we used point-mutated recombinant mGal-2 proteins to study which of the two highly conserved Cys residues in mGal-2 must be S-nitrosylated for protection against oxidative inactivation. Mutation of Cys 57 to a Met residue (C57M) did not result in lectin inactivation following H 2 O 2 treatment, whereas Cys 75 mutation to Ser (C75S) led to significantly reduced lectin activity, as is the case for wild-type mGal-2. However, pre-treatment of the C75S mutant with S-nitrosocysteine protected the protein from H 2 O 2 -induced inactivation. Therefore, Cys 57 is suggested to be responsible for oxidative inactivation of the mGal-2 protein, and protection of the sulfhydryl group of the Cys 57 in mGal-2 by S-nitrosylation is likely important for maintaining mGal-2 protein function in an oxidative environment such as the gastrointestinal tract." @default.
• W2342701607 created "2016-06-24" @default.
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• W2342701607 date "2016-04-27" @default.
• W2342701607 modified "2023-09-25" @default.
• W2342701607 title "Identification of the cysteine residue responsible for oxidative inactivation of mouse galectin-2" @default.
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• W2342701607 doi "https://doi.org/10.1093/jb/mvw029" @default.
• W2342701607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27122052" @default.
• W2342701607 hasPublicationYear "2016" @default.
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