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• W2342798889 endingPage "34419" @default.
• W2342798889 startingPage "34395" @default.
• W2342798889 abstract "Acquired drug resistance is a primary obstacle for effective cancer therapy. The correlation of point mutations in class III β-tubulin (TUBB3) and the prominent overexpression of ATP-binding cassette P-glycoprotein (ABCB1), a multidrug resistance gene, have been protruding mechanisms of resistance to microtubule disruptors such as paclitaxel (PTX) for many cancers. However, the precise underlying mechanism of the rapid onset of cross-resistance to an array of structurally and functionally unrelated drugs in PTX-resistant cancers has been poorly understood. We determined that our established PTX-resistant cancer cells display ABCB1/ABCC1-associated cross-resistance to chemically different drugs such as 5-fluorouracil, docetaxel, and cisplatin. We found that feedback activation of TUBB3 can be triggered through the FOXO3a-dependent regulation of ABCB1, which resulted in the accentuation of induced PTX resistance and encouraged multiplicity in acquired cross-resistance. FOXO3a-directed regulation of P-glycoprotein (P-gp) function suggests that control of ABCB1 involves methylation-dependent activation. Consistently, transcriptional overexpression or downregulation of FOXO3a directs inhibitor-controlled protease-degradation of TUBB3. The functional PI3K/Akt signaling is tightly responsive to FOXO3a activation alongside doxorubicin treatment, which directs FOXO3a arginine hypermethylation. In addition, we found that secretome factors from PTX-resistant cancer cells with acquired cross-resistance support a P-gp-dependent association in multidrug resistance (MDR) development, which assisted the FOXO3a-mediated control of TUBB3 feedback. The direct silencing of TUBB3 reverses induced multiple cross-resistance, reduces drug-resistant tumor mass, and suppresses the impaired microtubule stability status of PTX-resistant cells with transient cross-resistance. These findings highlight the control of the TUBB3 response to ABCB1 genetic suppressors as a mechanism to reverse the profuse development of multidrug resistance in cancer." @default.
• W2342798889 created "2016-06-24" @default.
• W2342798889 creator A5027490853 @default.
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• W2342798889 creator A5089594601 @default.
• W2342798889 date "2016-04-30" @default.
• W2342798889 modified "2023-10-12" @default.
• W2342798889 title "Multiplicity of acquired cross-resistance in paclitaxel-resistant cancer cells is associated with feedback control of TUBB3 via FOXO3a-mediated ABCB1 regulation" @default.
• W2342798889 cites W1570706727 @default.
• W2342798889 cites W1596218420 @default.
• W2342798889 cites W1760813225 @default.
• W2342798889 cites W1817954824 @default.
• W2342798889 cites W1900778087 @default.
• W2342798889 cites W1951996872 @default.
• W2342798889 cites W1966070413 @default.
• W2342798889 cites W1970634781 @default.
• W2342798889 cites W1982066209 @default.
• W2342798889 cites W1985097493 @default.
• W2342798889 cites W1988975697 @default.
• W2342798889 cites W1996181756 @default.
• W2342798889 cites W1996551392 @default.
• W2342798889 cites W1997863391 @default.
• W2342798889 cites W1999025555 @default.
• W2342798889 cites W2000021455 @default.
• W2342798889 cites W2002570701 @default.
• W2342798889 cites W2006434892 @default.
• W2342798889 cites W2012161830 @default.
• W2342798889 cites W2014120796 @default.
• W2342798889 cites W2016987827 @default.
• W2342798889 cites W2023244926 @default.
• W2342798889 cites W2023727725 @default.
• W2342798889 cites W2023902191 @default.
• W2342798889 cites W2026322409 @default.
• W2342798889 cites W2027408970 @default.
• W2342798889 cites W2027573328 @default.
• W2342798889 cites W2030337403 @default.
• W2342798889 cites W2031909042 @default.
• W2342798889 cites W2034201098 @default.
• W2342798889 cites W2034979953 @default.
• W2342798889 cites W2046655465 @default.
• W2342798889 cites W2047307361 @default.
• W2342798889 cites W2049135828 @default.
• W2342798889 cites W2050671819 @default.
• W2342798889 cites W2055397209 @default.
• W2342798889 cites W2059724105 @default.
• W2342798889 cites W2068408268 @default.
• W2342798889 cites W2071001421 @default.
• W2342798889 cites W2074943381 @default.
• W2342798889 cites W2076174368 @default.
• W2342798889 cites W2076194625 @default.
• W2342798889 cites W2081486143 @default.
• W2342798889 cites W2082486482 @default.
• W2342798889 cites W2087038374 @default.
• W2342798889 cites W2089492721 @default.
• W2342798889 cites W2090080713 @default.
• W2342798889 cites W2090546918 @default.
• W2342798889 cites W2092437923 @default.
• W2342798889 cites W2093855538 @default.
• W2342798889 cites W2094769960 @default.
• W2342798889 cites W2095558022 @default.
• W2342798889 cites W2097982283 @default.
• W2342798889 cites W2098514397 @default.
• W2342798889 cites W2100892574 @default.
• W2342798889 cites W2101096891 @default.
• W2342798889 cites W2102365935 @default.
• W2342798889 cites W2109733561 @default.
• W2342798889 cites W2112451226 @default.
• W2342798889 cites W2114594486 @default.
• W2342798889 cites W2115202941 @default.
• W2342798889 cites W2119893163 @default.
• W2342798889 cites W2122952132 @default.
• W2342798889 cites W2125910276 @default.
• W2342798889 cites W2126102004 @default.
• W2342798889 cites W2130444978 @default.
• W2342798889 cites W2134055799 @default.
• W2342798889 cites W2136946693 @default.
• W2342798889 cites W2139627575 @default.
• W2342798889 cites W2141605867 @default.
• W2342798889 cites W2144749842 @default.
• W2342798889 cites W2147807172 @default.
• W2342798889 cites W2151388261 @default.
• W2342798889 cites W2154007629 @default.
• W2342798889 cites W2154322675 @default.
• W2342798889 cites W2154747925 @default.
• W2342798889 cites W2158587776 @default.
• W2342798889 cites W2161767853 @default.
• W2342798889 cites W2163455902 @default.
• W2342798889 cites W2164617822 @default.
• W2342798889 cites W2168443282 @default.
• W2342798889 cites W2171071516 @default.
• W2342798889 cites W2406567577 @default.
• W2342798889 cites W2486272530 @default.
• W2342798889 cites W2103531348 @default.
• W2342798889 doi "https://doi.org/10.18632/oncotarget.9118" @default.
• W2342798889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5085164" @default.
• W2342798889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27284014" @default.

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