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- W2342818076 abstract "Untreated, or incompletely treated, depression in pregnancy is associated with postpartum and chronic maternal depression and a negative impact on infant and child developmental outcomes. Therefore, it follows that treatment of depression during pregnancy should act to promote maternal health and, by extension, child development and behavior. However, the article by Malm et al.1 Malm H. Brown A.S. Gissler M. et al. Gestational exposure to selective serotonin reuptake inhibitors and offspring psychiatric disorders: a national register-based study. J Am Acad Child Adolesc Psychiatry. 2016; 55: 359-366 Abstract Full Text Full Text PDF PubMed Scopus (147) Google Scholar raises critical questions about long-term developmental consequences associated with in utero exposure to one of the most common and effective treatments for depression—selective serotonin reuptake inhibitor (SSRI) antidepressants. At first glance, it appears paradoxical that prenatal exposure to the very medication used to treat depression would be associated with a subsequent increased risk for the same disorder. However, because of the key role serotonin (5HT) plays in early brain development, research has shifted toward the impact of SSRIs in utero on long-term neurobehavioral outcomes. 2 Hanley G.E. Brain U. Oberlander T.F. Prenatal exposure to serotonin reuptake inhibitor antidepressants and childhood behavior. Pediatr Res. 2015; 78: 174-180 Crossref Scopus (60) Google Scholar Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders: A National Register-Based StudyJournal of the American Academy of Child & Adolescent PsychiatryVol. 55Issue 5PreviewTo investigate the impact of gestational exposure to selective serotonin reuptake inhibitors (SSRIs) on offspring neurodevelopment. Full-Text PDF" @default.
- W2342818076 created "2016-06-24" @default.
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- W2342818076 date "2016-05-01" @default.
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- W2342818076 title "Developmental Effects of Prenatal Selective Serotonin Reuptake Inhibitor Exposure in Perspective: Are We Comparing Apples to Apples?" @default.
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- W2342818076 doi "https://doi.org/10.1016/j.jaac.2016.02.012" @default.
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