FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342854452> ?p ?o ?g. }

• W2342854452 abstract "The pathophysiologic role of the Philadelphia chromosome translocation in chronic myelogenous leukemia (CML) has been known for nearly 20 years. However, the most significant morbidity and mortality in CML are caused by progression to blast crisis, about which comparatively little is known at the molecular level. Genomic imprinting is a chromosomal modification leading to parental-origin–specific gene expression in somatic cells. Recently, we and others have described loss of imprinting (LOI) of the insulin-like growth factor-II gene (IGF2), leading to biallelic rather than monoallelic expression in a wide variety of solid tumors. We have now examined the imprinting status of IGF2 in samples from CML patients in stable phase, accelerated phase, and blast crisis. Five of six stable-phase patients showed normal imprinting, but LOI was found in all six cases of advanced disease (three accelerated phase, three blast crisis), which was statistically highly significant (P < .01). Thus, LOI represents a novel type of genetic alteration in CML that appears to be specifically associated with disease progression." @default.
• W2342854452 created "2016-06-24" @default.
• W2342854452 creator A5000106724 @default.
• W2342854452 creator A5011529063 @default.
• W2342854452 creator A5014877107 @default.
• W2342854452 creator A5033951791 @default.
• W2342854452 creator A5035789655 @default.
• W2342854452 creator A5048913229 @default.
• W2342854452 creator A5066640903 @default.
• W2342854452 creator A5082643317 @default.
• W2342854452 creator A5090435894 @default.
• W2342854452 date "1998-05-01" @default.
• W2342854452 modified "2023-10-06" @default.
• W2342854452 title "Loss of Imprinting in Disease Progression in Chronic Myelogenous Leukemia" @default.
• W2342854452 cites W126478523 @default.
• W2342854452 cites W1967588153 @default.
• W2342854452 cites W1985014165 @default.
• W2342854452 cites W2018574431 @default.
• W2342854452 cites W2020708296 @default.
• W2342854452 cites W2024925903 @default.
• W2342854452 cites W2026824752 @default.
• W2342854452 cites W2028964252 @default.
• W2342854452 cites W2035656617 @default.
• W2342854452 cites W2036733820 @default.
• W2342854452 cites W2082668438 @default.
• W2342854452 cites W2105650844 @default.
• W2342854452 cites W2141603904 @default.
• W2342854452 cites W2166529301 @default.
• W2342854452 cites W2244637994 @default.
• W2342854452 cites W2396892382 @default.
• W2342854452 cites W287390018 @default.
• W2342854452 cites W345521180 @default.
• W2342854452 cites W4252556199 @default.
• W2342854452 doi "https://doi.org/10.1182/blood.v91.9.3144.3144_3144_3147" @default.
• W2342854452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9558368" @default.
• W2342854452 hasPublicationYear "1998" @default.
• W2342854452 type Work @default.
• W2342854452 sameAs 2342854452 @default.
• W2342854452 citedByCount "31" @default.
• W2342854452 countsByYear W23428544522012 @default.
• W2342854452 countsByYear W23428544522013 @default.
• W2342854452 countsByYear W23428544522015 @default.
• W2342854452 countsByYear W23428544522016 @default.
• W2342854452 countsByYear W23428544522017 @default.
• W2342854452 countsByYear W23428544522018 @default.
• W2342854452 countsByYear W23428544522023 @default.
• W2342854452 crossrefType "journal-article" @default.
• W2342854452 hasAuthorship W2342854452A5000106724 @default.
• W2342854452 hasAuthorship W2342854452A5011529063 @default.
• W2342854452 hasAuthorship W2342854452A5014877107 @default.
• W2342854452 hasAuthorship W2342854452A5033951791 @default.
• W2342854452 hasAuthorship W2342854452A5035789655 @default.
• W2342854452 hasAuthorship W2342854452A5048913229 @default.
• W2342854452 hasAuthorship W2342854452A5066640903 @default.
• W2342854452 hasAuthorship W2342854452A5082643317 @default.
• W2342854452 hasAuthorship W2342854452A5090435894 @default.
• W2342854452 hasBestOaLocation W23428544521 @default.
• W2342854452 hasConcept C104317684 @default.
• W2342854452 hasConcept C126322002 @default.
• W2342854452 hasConcept C138626823 @default.
• W2342854452 hasConcept C150194340 @default.
• W2342854452 hasConcept C190727270 @default.
• W2342854452 hasConcept C201492766 @default.
• W2342854452 hasConcept C203014093 @default.
• W2342854452 hasConcept C2776960273 @default.
• W2342854452 hasConcept C2778461978 @default.
• W2342854452 hasConcept C2778904597 @default.
• W2342854452 hasConcept C2779134260 @default.
• W2342854452 hasConcept C502942594 @default.
• W2342854452 hasConcept C54355233 @default.
• W2342854452 hasConcept C71924100 @default.
• W2342854452 hasConcept C86803240 @default.
• W2342854452 hasConcept C94715292 @default.
• W2342854452 hasConceptScore W2342854452C104317684 @default.
• W2342854452 hasConceptScore W2342854452C126322002 @default.
• W2342854452 hasConceptScore W2342854452C138626823 @default.
• W2342854452 hasConceptScore W2342854452C150194340 @default.
• W2342854452 hasConceptScore W2342854452C190727270 @default.
• W2342854452 hasConceptScore W2342854452C201492766 @default.
• W2342854452 hasConceptScore W2342854452C203014093 @default.
• W2342854452 hasConceptScore W2342854452C2776960273 @default.
• W2342854452 hasConceptScore W2342854452C2778461978 @default.
• W2342854452 hasConceptScore W2342854452C2778904597 @default.
• W2342854452 hasConceptScore W2342854452C2779134260 @default.
• W2342854452 hasConceptScore W2342854452C502942594 @default.
• W2342854452 hasConceptScore W2342854452C54355233 @default.
• W2342854452 hasConceptScore W2342854452C71924100 @default.
• W2342854452 hasConceptScore W2342854452C86803240 @default.
• W2342854452 hasConceptScore W2342854452C94715292 @default.
• W2342854452 hasLocation W23428544521 @default.
• W2342854452 hasOpenAccess W2342854452 @default.
• W2342854452 hasPrimaryLocation W23428544521 @default.
• W2342854452 hasRelatedWork W1505779395 @default.
• W2342854452 hasRelatedWork W1552716393 @default.
• W2342854452 hasRelatedWork W1567533051 @default.
• W2342854452 hasRelatedWork W1643500256 @default.
• W2342854452 hasRelatedWork W1669374546 @default.
• W2342854452 hasRelatedWork W1679961940 @default.
• W2342854452 hasRelatedWork W1967588153 @default.
• W2342854452 hasRelatedWork W1978056808 @default.

• next