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• W2342873461 abstract "It has been shown previously that peripheral blood lymphocytes from normal dogs cocultured with DLA-identical littermate marrow increased the number of erythroid colonies over that obtained with marrow alone. In contrast, preceding blood transfusion from the littermate reduced the ability of lymphocytes to enhance erythroid colony growth. The current study correlates similar findings in vitro with the observations made in vivo following marrow transplantation after lethal total body irradiation. Twenty pairs of DLA-identical littermates were studied. One member of each pair served as the blood and marrow donor and the other as the recipient. Each recipient was “sensitized” by transfusion of blood products from their prospective donor. Of 20 transfused recipients, 14 rejected the marrow graft; 13 of these 14 rejections were predicted by observation in vitro of either lack of stimulation or inhibition of donor marrow by recipient lymphocytes. Successful and sustained marrow engraftment occurred in 6 dogs; 5 of these were associated with significant stimulation of donor marrow in coculture. These results were significant at p = 0.002 and suggest that transfusion-induced sensitization and marrow graft rejection can be predicted by reduced erythroid colony growth of donor marrow cocultured with recipient lymphocytes." @default.
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• W2342873461 date "1979-01-01" @default.
• W2342873461 modified "2023-10-06" @default.
• W2342873461 title "Growth in vitro of donor marrow cultured with recipient lymphocytes predicts the fate of marrow grafts in transfused DLA-identical dogs" @default.
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• W2342873461 doi "https://doi.org/10.1182/blood.v53.1.104.104" @default.
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