Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342909560> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2342909560 endingPage "45" @default.
- W2342909560 startingPage "40" @default.
- W2342909560 abstract "To compare chemoradiation with cisplatin alone or cisplatin plus 5-FU for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN). The outcomes of 142 patients who received chemoradiation with cisplatin alone for locally advanced SCCHN were retrospectively compared to 170 patients who received cisplatin plus 5-fluorouracil (5-FU). The outcomes compared included loco-regional control (LRC), metastases-free survival (MFS), overall survival (OS) and adverse events. Although patients who received cisplatin alone had a significantly worse performance status, 81% of these patients completed planned chemotherapy compared to 73% of patients in the cisplatin plus 5-FU group (p = 0.18). Radiotherapy breaks >1 week were necessary in 14% and 23% of patients, respectively (p = 0.09). The 5-year LRC rates were 69% after cisplatin alone and 68% after cisplatin plus 5-FU (p = 0.71). The 5-year MFS rates were 72% and 62%, respectively (p = 0.37), and 5-year OS rates were 60% and 45%, respectively (p = 0.066). On multivariate analysis, cisplatin alone was significantly associated with improved OS (RR 1.35; 95%-CI 1.09–1.69; p = 0.006). Nausea/vomiting, pneumonia/sepsis and late adverse events occurred more common in the cisplatin plus 5-FU group. Given the limitations of a retrospective study, chemoradiation with cisplatin alone appeared associated with fewer adverse events and better OS than with cisplatin plus 5-FU in patients with locally advanced SCCHN. Thus, 5-FU in addition to cisplatin may be omitted for these patients. A randomized trial is warranted to confirm these findings." @default.
- W2342909560 created "2016-06-24" @default.
- W2342909560 creator A5015792408 @default.
- W2342909560 creator A5034062838 @default.
- W2342909560 creator A5039322947 @default.
- W2342909560 creator A5041640980 @default.
- W2342909560 creator A5057206849 @default.
- W2342909560 creator A5062848479 @default.
- W2342909560 creator A5065650315 @default.
- W2342909560 date "2016-06-01" @default.
- W2342909560 modified "2023-09-30" @default.
- W2342909560 title "Do we need 5-FU in addition to cisplatin for chemoradiation of locally advanced head-and-neck cancer?" @default.
- W2342909560 cites W1138664098 @default.
- W2342909560 cites W1533439633 @default.
- W2342909560 cites W1784479792 @default.
- W2342909560 cites W1973492538 @default.
- W2342909560 cites W1998491010 @default.
- W2342909560 cites W2062253457 @default.
- W2342909560 cites W2065431556 @default.
- W2342909560 cites W2066334626 @default.
- W2342909560 cites W2089257078 @default.
- W2342909560 cites W2097064667 @default.
- W2342909560 cites W2113541736 @default.
- W2342909560 cites W2115794884 @default.
- W2342909560 cites W2120068217 @default.
- W2342909560 cites W2142222095 @default.
- W2342909560 cites W2145078756 @default.
- W2342909560 cites W2155019837 @default.
- W2342909560 cites W2157627057 @default.
- W2342909560 cites W2172200669 @default.
- W2342909560 cites W2186186182 @default.
- W2342909560 cites W2402080091 @default.
- W2342909560 cites W4293241248 @default.
- W2342909560 doi "https://doi.org/10.1016/j.oraloncology.2016.04.003" @default.
- W2342909560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27208843" @default.
- W2342909560 hasPublicationYear "2016" @default.
- W2342909560 type Work @default.
- W2342909560 sameAs 2342909560 @default.
- W2342909560 citedByCount "10" @default.
- W2342909560 countsByYear W23429095602016 @default.
- W2342909560 countsByYear W23429095602017 @default.
- W2342909560 countsByYear W23429095602020 @default.
- W2342909560 countsByYear W23429095602021 @default.
- W2342909560 countsByYear W23429095602022 @default.
- W2342909560 countsByYear W23429095602023 @default.
- W2342909560 crossrefType "journal-article" @default.
- W2342909560 hasAuthorship W2342909560A5015792408 @default.
- W2342909560 hasAuthorship W2342909560A5034062838 @default.
- W2342909560 hasAuthorship W2342909560A5039322947 @default.
- W2342909560 hasAuthorship W2342909560A5041640980 @default.
- W2342909560 hasAuthorship W2342909560A5057206849 @default.
- W2342909560 hasAuthorship W2342909560A5062848479 @default.
- W2342909560 hasAuthorship W2342909560A5065650315 @default.
- W2342909560 hasConcept C126322002 @default.
- W2342909560 hasConcept C143998085 @default.
- W2342909560 hasConcept C197934379 @default.
- W2342909560 hasConcept C2776530083 @default.
- W2342909560 hasConcept C2776694085 @default.
- W2342909560 hasConcept C2777793932 @default.
- W2342909560 hasConcept C2778239845 @default.
- W2342909560 hasConcept C2778424827 @default.
- W2342909560 hasConcept C2780456651 @default.
- W2342909560 hasConcept C2780580376 @default.
- W2342909560 hasConcept C509974204 @default.
- W2342909560 hasConcept C71924100 @default.
- W2342909560 hasConceptScore W2342909560C126322002 @default.
- W2342909560 hasConceptScore W2342909560C143998085 @default.
- W2342909560 hasConceptScore W2342909560C197934379 @default.
- W2342909560 hasConceptScore W2342909560C2776530083 @default.
- W2342909560 hasConceptScore W2342909560C2776694085 @default.
- W2342909560 hasConceptScore W2342909560C2777793932 @default.
- W2342909560 hasConceptScore W2342909560C2778239845 @default.
- W2342909560 hasConceptScore W2342909560C2778424827 @default.
- W2342909560 hasConceptScore W2342909560C2780456651 @default.
- W2342909560 hasConceptScore W2342909560C2780580376 @default.
- W2342909560 hasConceptScore W2342909560C509974204 @default.
- W2342909560 hasConceptScore W2342909560C71924100 @default.
- W2342909560 hasLocation W23429095601 @default.
- W2342909560 hasLocation W23429095602 @default.
- W2342909560 hasOpenAccess W2342909560 @default.
- W2342909560 hasPrimaryLocation W23429095601 @default.
- W2342909560 hasRelatedWork W2046102541 @default.
- W2342909560 hasRelatedWork W2342909560 @default.
- W2342909560 hasRelatedWork W2358431917 @default.
- W2342909560 hasRelatedWork W2406263212 @default.
- W2342909560 hasRelatedWork W2409439767 @default.
- W2342909560 hasRelatedWork W2430773826 @default.
- W2342909560 hasRelatedWork W2460868461 @default.
- W2342909560 hasRelatedWork W3012537123 @default.
- W2342909560 hasRelatedWork W3028665314 @default.
- W2342909560 hasRelatedWork W4308006065 @default.
- W2342909560 hasVolume "57" @default.
- W2342909560 isParatext "false" @default.
- W2342909560 isRetracted "false" @default.
- W2342909560 magId "2342909560" @default.
- W2342909560 workType "article" @default.