Matches in SemOpenAlex for { <https://semopenalex.org/work/W2342962008> ?p ?o ?g. }
- W2342962008 abstract "Translation is a core cellular process carried out by a highly conserved macromolecular machine, the ribosome. There has been remarkable evolutionary adaptation of this machine through the addition of eukaryote-specific ribosomal proteins whose individual effects on ribosome function are largely unknown. Here we show that eukaryote-specific Asc1/RACK1 is required for efficient translation of mRNAs with short open reading frames that show greater than average translational efficiency in diverse eukaryotes. ASC1 mutants in S. cerevisiae display compromised translation of specific functional groups, including cytoplasmic and mitochondrial ribosomal proteins, and display cellular phenotypes consistent with their gene-specific translation defects. Asc1-sensitive mRNAs are preferentially associated with the translational ‘closed loop’ complex comprised of eIF4E, eIF4G, and Pab1, and depletion of eIF4G mimics the translational defects of ASC1 mutants. Together our results reveal a role for Asc1/RACK1 in a length-dependent initiation mechanism optimized for efficient translation of genes with important housekeeping functions." @default.
- W2342962008 created "2016-06-24" @default.
- W2342962008 creator A5034817391 @default.
- W2342962008 creator A5054745665 @default.
- W2342962008 creator A5061198989 @default.
- W2342962008 creator A5082909871 @default.
- W2342962008 date "2016-04-27" @default.
- W2342962008 modified "2023-10-17" @default.
- W2342962008 title "The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs" @default.
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- W2342962008 doi "https://doi.org/10.7554/elife.11154" @default.
- W2342962008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4848094" @default.
- W2342962008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27117520" @default.
- W2342962008 hasPublicationYear "2016" @default.
- W2342962008 type Work @default.
- W2342962008 sameAs 2342962008 @default.