Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343064318> ?p ?o ?g. }
- W2343064318 endingPage "1187" @default.
- W2343064318 startingPage "1172" @default.
- W2343064318 abstract "A new set of cyclooxygenase (COX) inhibitors endowed with an additional functionality was explored. These new compounds also contained either rhodamine 6G or 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, two moieties typical of efflux pump substrates and inhibitors, respectively. Among all the synthesized compounds, two new COX inhibitors with opposite selectivity were discovered: compound 8 [N-(9-{2-[(4-{2-[3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]acetamido}butyl)carbamoyl]phenyl-6-(ethylamino)-2,7-dimethyl-3H-xanthen-3-ylidene}ethanaminium chloride] was found to be a selective COX-1 inhibitor, whereas 17 (2-[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]-1-[6,7-dimethoxy-3,4-dihydroisoquinolin-2-(1H)-yl]ethanone) was found to be a sub-micromolar selective COX-2 inhibitor. However, both were shown to interact with P-glycoprotein. Docking experiments helped to clarify the molecular aspects of the observed COX selectivity." @default.
- W2343064318 created "2016-06-24" @default.
- W2343064318 creator A5000511616 @default.
- W2343064318 creator A5022332479 @default.
- W2343064318 creator A5026352630 @default.
- W2343064318 creator A5054163069 @default.
- W2343064318 creator A5083327774 @default.
- W2343064318 creator A5084377263 @default.
- W2343064318 creator A5089166509 @default.
- W2343064318 date "2016-05-02" @default.
- W2343064318 modified "2023-10-16" @default.
- W2343064318 title "Isoxazole-Based-Scaffold Inhibitors Targeting Cyclooxygenases (COXs)" @default.
- W2343064318 cites W1964909390 @default.
- W2343064318 cites W1966268766 @default.
- W2343064318 cites W1974412827 @default.
- W2343064318 cites W1979715761 @default.
- W2343064318 cites W1991422271 @default.
- W2343064318 cites W2010251888 @default.
- W2343064318 cites W2010897074 @default.
- W2343064318 cites W2012344270 @default.
- W2343064318 cites W2022863010 @default.
- W2343064318 cites W2023302278 @default.
- W2343064318 cites W2026321461 @default.
- W2343064318 cites W2026404015 @default.
- W2343064318 cites W2030850720 @default.
- W2343064318 cites W2033707421 @default.
- W2343064318 cites W2037115363 @default.
- W2343064318 cites W2041718021 @default.
- W2343064318 cites W2042488807 @default.
- W2343064318 cites W2044049931 @default.
- W2343064318 cites W2050456292 @default.
- W2343064318 cites W2052030759 @default.
- W2343064318 cites W2053848658 @default.
- W2343064318 cites W2056298354 @default.
- W2343064318 cites W2067391745 @default.
- W2343064318 cites W2070481035 @default.
- W2343064318 cites W2071357022 @default.
- W2343064318 cites W2077204925 @default.
- W2343064318 cites W2079406594 @default.
- W2343064318 cites W2105629587 @default.
- W2343064318 cites W2108982217 @default.
- W2343064318 cites W2112260434 @default.
- W2343064318 cites W2120151190 @default.
- W2343064318 cites W2131458350 @default.
- W2343064318 cites W2139945318 @default.
- W2343064318 cites W2146306600 @default.
- W2343064318 cites W2150155770 @default.
- W2343064318 cites W2169411643 @default.
- W2343064318 cites W2313067521 @default.
- W2343064318 cites W2318605976 @default.
- W2343064318 doi "https://doi.org/10.1002/cmdc.201500439" @default.
- W2343064318 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27136372" @default.
- W2343064318 hasPublicationYear "2016" @default.
- W2343064318 type Work @default.
- W2343064318 sameAs 2343064318 @default.
- W2343064318 citedByCount "16" @default.
- W2343064318 countsByYear W23430643182016 @default.
- W2343064318 countsByYear W23430643182017 @default.
- W2343064318 countsByYear W23430643182018 @default.
- W2343064318 countsByYear W23430643182019 @default.
- W2343064318 countsByYear W23430643182020 @default.
- W2343064318 countsByYear W23430643182021 @default.
- W2343064318 countsByYear W23430643182023 @default.
- W2343064318 crossrefType "journal-article" @default.
- W2343064318 hasAuthorship W2343064318A5000511616 @default.
- W2343064318 hasAuthorship W2343064318A5022332479 @default.
- W2343064318 hasAuthorship W2343064318A5026352630 @default.
- W2343064318 hasAuthorship W2343064318A5054163069 @default.
- W2343064318 hasAuthorship W2343064318A5083327774 @default.
- W2343064318 hasAuthorship W2343064318A5084377263 @default.
- W2343064318 hasAuthorship W2343064318A5089166509 @default.
- W2343064318 hasBestOaLocation W23430643182 @default.
- W2343064318 hasConcept C118792377 @default.
- W2343064318 hasConcept C161790260 @default.
- W2343064318 hasConcept C181199279 @default.
- W2343064318 hasConcept C185592680 @default.
- W2343064318 hasConcept C200082930 @default.
- W2343064318 hasConcept C21951064 @default.
- W2343064318 hasConcept C2778866207 @default.
- W2343064318 hasConcept C2779689624 @default.
- W2343064318 hasConcept C2781269603 @default.
- W2343064318 hasConcept C55493867 @default.
- W2343064318 hasConcept C71240020 @default.
- W2343064318 hasConceptScore W2343064318C118792377 @default.
- W2343064318 hasConceptScore W2343064318C161790260 @default.
- W2343064318 hasConceptScore W2343064318C181199279 @default.
- W2343064318 hasConceptScore W2343064318C185592680 @default.
- W2343064318 hasConceptScore W2343064318C200082930 @default.
- W2343064318 hasConceptScore W2343064318C21951064 @default.
- W2343064318 hasConceptScore W2343064318C2778866207 @default.
- W2343064318 hasConceptScore W2343064318C2779689624 @default.
- W2343064318 hasConceptScore W2343064318C2781269603 @default.
- W2343064318 hasConceptScore W2343064318C55493867 @default.
- W2343064318 hasConceptScore W2343064318C71240020 @default.
- W2343064318 hasIssue "11" @default.
- W2343064318 hasLocation W23430643181 @default.
- W2343064318 hasLocation W23430643182 @default.
- W2343064318 hasLocation W23430643183 @default.