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• W2343138892 abstract "OBJECTIVE MicroRNAs (miRNAs) regulate gene expression and therefore play important roles in many physiological and pathological processes. The aim of this pilot study was to determine the feasibility of extraction and subsequent profiling of miRNA from CSF samples in a pilot population of aneurysmal subarachnoid hemorrhage patients and establish if there is a distinct CSF miRNA signature between patients who develop cerebral vasospasm and those who do not. METHODS CSF samples were taken at various time points during the clinical management of a subset of SAH patients (SAH patient samples without vasospasm, n = 10; SAH patient samples with vasospasm, n = 10). CSF obtained from 4 patients without SAH was also included in the analysis. The miRNA was subsequently isolated and purified and then analyzed on an nCounter instrument using the Human V2 and V3 miRNA assay kits. The data were imported into the nSolver software package for differential miRNA expression analysis. RESULTS From a total of 800 miRNAs that could be detected with each version of the miRNA assay kit, a total of 691 miRNAs were communal to both kits. There were 36 individual miRNAs that were differentially expressed (p < 0.01) based on group analyses, with a number of miRNAs showing significant changes in more than one group analysis. The changes largely reflected differences between non-SAH and SAH groups. These included miR-204-5p, miR-223-3p, miR-337-5p, miR-451a, miR-489, miR-508-3p, miR-514-3p, miR-516-5p, miR-548 m, miR-599, miR-937, miR-1224-3p, and miR-1301. However, a number of miRNAs did exclusively differ between the vasospasm and nonvasospasm SAH groups including miR-27a-3p, miR-516a-5p, miR-566, and miR-1197. CONCLUSIONS The findings indicate that temporal miRNA profiling can detect differences between CSF from aneurysmal SAH and non-SAH patients. Moreover, the miRNA profile of CSF samples from patients who develop cerebral vasopasm may be distinguishable from those who do not. These results provide a foundation for future research at identifying novel CSF biomarkers that might predispose to the development of cerebral vasospasm after SAH and therefore influence subsequent clinical management." @default.
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• W2343138892 date "2017-04-01" @default.
• W2343138892 modified "2023-10-14" @default.
• W2343138892 title "miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage" @default.
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• W2343138892 cites W1971234948 @default.
• W2343138892 cites W1975203744 @default.
• W2343138892 cites W1975437957 @default.
• W2343138892 cites W1975448513 @default.
• W2343138892 cites W1979587260 @default.
• W2343138892 cites W1980876408 @default.
• W2343138892 cites W1996415723 @default.
• W2343138892 cites W1996630410 @default.
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• W2343138892 cites W2008168566 @default.
• W2343138892 cites W2008945738 @default.
• W2343138892 cites W2011500268 @default.
• W2343138892 cites W2013454926 @default.
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• W2343138892 cites W2016106370 @default.
• W2343138892 cites W2017947530 @default.
• W2343138892 cites W2018780848 @default.
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• W2343138892 cites W2026570544 @default.
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• W2343138892 cites W2031750327 @default.
• W2343138892 cites W2034384985 @default.
• W2343138892 cites W2048678784 @default.
• W2343138892 cites W2050667838 @default.
• W2343138892 cites W2054812087 @default.
• W2343138892 cites W2061404129 @default.
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• W2343138892 doi "https://doi.org/10.3171/2016.1.jns151454" @default.
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