Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343176180> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- W2343176180 endingPage "81" @default.
- W2343176180 startingPage "175" @default.
- W2343176180 abstract "Current standard-of-care therapy for HCV infection, comprising a combination of IFNalpha and ribavirin (IFN/Rib), is ineffective in more than 50% of patients, and is associated with poor patient compliance and high cost. The recent development of an infectious culture system for HCV has allowed investigators to target the complete life cycle of the virus in an attempt to develop new, virus-specific drugs. Compounds specific for classical HCV targets, such as the viral protease and polymerase, have reached phase II/III clinical trials, and encouraging results have indicated that these virus-specific compounds may complement and eventually replace therapy with IFN/Rib. However, the variable nature of HCV (quasispecies and genotype variation) and the limited number of compounds developed thus far have prompted research aimed at expanding the repertoire of available targets, resulting in processes such as virus assembly being targeted therapeutically. The viral ion channel p7 is critical for the release of HCV virions, and the sensitivity of this channel to small-molecule inhibitors renders p7 a promising target for novel therapies. Small-molecule p7 inhibitors, although at an early stage of development, block virion production in culture effectively, and limited clinical data, although controversial because of the variable antiviral effects observed, suggest that p7 inhibitors could represent effective additions to combination therapies with other virus-specific drugs." @default.
- W2343176180 created "2016-06-24" @default.
- W2343176180 creator A5035603259 @default.
- W2343176180 date "2010-02-01" @default.
- W2343176180 modified "2023-10-18" @default.
- W2343176180 title "Inhibition of HCV p7 as a therapeutic target." @default.
- W2343176180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20112167" @default.
- W2343176180 hasPublicationYear "2010" @default.
- W2343176180 type Work @default.
- W2343176180 sameAs 2343176180 @default.
- W2343176180 citedByCount "4" @default.
- W2343176180 countsByYear W23431761802013 @default.
- W2343176180 countsByYear W23431761802016 @default.
- W2343176180 countsByYear W23431761802018 @default.
- W2343176180 crossrefType "journal-article" @default.
- W2343176180 hasAuthorship W2343176180A5035603259 @default.
- W2343176180 hasConcept C14500911 @default.
- W2343176180 hasConcept C159047783 @default.
- W2343176180 hasConcept C203014093 @default.
- W2343176180 hasConcept C2522874641 @default.
- W2343176180 hasConcept C2776408679 @default.
- W2343176180 hasConcept C2780040827 @default.
- W2343176180 hasConcept C71924100 @default.
- W2343176180 hasConceptScore W2343176180C14500911 @default.
- W2343176180 hasConceptScore W2343176180C159047783 @default.
- W2343176180 hasConceptScore W2343176180C203014093 @default.
- W2343176180 hasConceptScore W2343176180C2522874641 @default.
- W2343176180 hasConceptScore W2343176180C2776408679 @default.
- W2343176180 hasConceptScore W2343176180C2780040827 @default.
- W2343176180 hasConceptScore W2343176180C71924100 @default.
- W2343176180 hasIssue "2" @default.
- W2343176180 hasLocation W23431761801 @default.
- W2343176180 hasOpenAccess W2343176180 @default.
- W2343176180 hasPrimaryLocation W23431761801 @default.
- W2343176180 hasRelatedWork W1995814590 @default.
- W2343176180 hasRelatedWork W1999725150 @default.
- W2343176180 hasRelatedWork W2064393624 @default.
- W2343176180 hasRelatedWork W2096288449 @default.
- W2343176180 hasRelatedWork W2152441522 @default.
- W2343176180 hasRelatedWork W2155354381 @default.
- W2343176180 hasRelatedWork W2474111263 @default.
- W2343176180 hasRelatedWork W2495310867 @default.
- W2343176180 hasRelatedWork W3140103548 @default.
- W2343176180 hasRelatedWork W3145102491 @default.
- W2343176180 hasVolume "11" @default.
- W2343176180 isParatext "false" @default.
- W2343176180 isRetracted "false" @default.
- W2343176180 magId "2343176180" @default.
- W2343176180 workType "article" @default.