FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343242243> ?p ?o ?g. }

• W2343242243 endingPage "C80" @default.
• W2343242243 startingPage "C67" @default.
• W2343242243 abstract "Mitochondrial Ca 2+ homeostasis, the Ca 2+ influx-efflux balance, is responsible for the control of numerous cellular functions, including energy metabolism, generation of reactive oxygen species, spatiotemporal dynamics of Ca 2+ signaling, and cell growth and death. Recent discovery of the molecular identity of the mitochondrial Ca 2+ uniporter (MCU) provides new possibilities for application of genetic approaches to study the mitochondrial Ca 2+ influx mechanism in various cell types and tissues. In addition, the subsequent discovery of various auxiliary subunits associated with MCU suggests that mitochondrial Ca 2+ uptake is not solely regulated by a single protein (MCU), but likely by a macromolecular protein complex, referred to as the MCU-protein complex (mtCUC). Moreover, recent reports have shown the potential role of MCU posttranslational modifications in the regulation of mitochondrial Ca 2+ uptake through mtCUC. These observations indicate that mtCUCs form a local signaling complex at the inner mitochondrial membrane that could significantly regulate mitochondrial Ca 2+ handling, as well as numerous mitochondrial and cellular functions. In this review we discuss the current literature on mitochondrial Ca 2+ uptake mechanisms, with a particular focus on the structure and function of mtCUC, as well as its regulation by signal transduction pathways, highlighting current controversies and discrepancies." @default.
• W2343242243 created "2016-06-24" @default.
• W2343242243 creator A5018770733 @default.
• W2343242243 creator A5019491267 @default.
• W2343242243 creator A5029968842 @default.
• W2343242243 creator A5030261747 @default.
• W2343242243 creator A5045005778 @default.
• W2343242243 creator A5055312806 @default.
• W2343242243 creator A5084809848 @default.
• W2343242243 date "2016-07-01" @default.
• W2343242243 modified "2023-10-11" @default.
• W2343242243 title "The mitochondrial Ca²⁺uniporter: regulation by auxiliary subunits and signal transduction pathways" @default.
• W2343242243 cites W1173363010 @default.
• W2343242243 cites W1486654044 @default.
• W2343242243 cites W150246076 @default.
• W2343242243 cites W1523821352 @default.
• W2343242243 cites W1547216871 @default.
• W2343242243 cites W1581917124 @default.
• W2343242243 cites W1616183675 @default.
• W2343242243 cites W1622243645 @default.
• W2343242243 cites W1777003639 @default.
• W2343242243 cites W1779480319 @default.
• W2343242243 cites W1816138368 @default.
• W2343242243 cites W1866433599 @default.
• W2343242243 cites W1947430131 @default.
• W2343242243 cites W1951756999 @default.
• W2343242243 cites W1964257657 @default.
• W2343242243 cites W1967184808 @default.
• W2343242243 cites W1967653238 @default.
• W2343242243 cites W1969709153 @default.
• W2343242243 cites W1969940696 @default.
• W2343242243 cites W1970610775 @default.
• W2343242243 cites W1972733511 @default.
• W2343242243 cites W1981748166 @default.
• W2343242243 cites W1986213783 @default.
• W2343242243 cites W1988741146 @default.
• W2343242243 cites W1991055482 @default.
• W2343242243 cites W1995989434 @default.
• W2343242243 cites W1998577671 @default.
• W2343242243 cites W2002475003 @default.
• W2343242243 cites W2002791298 @default.
• W2343242243 cites W2005641666 @default.
• W2343242243 cites W2009164248 @default.
• W2343242243 cites W2009657046 @default.
• W2343242243 cites W2010572143 @default.
• W2343242243 cites W2015536770 @default.
• W2343242243 cites W2016024763 @default.
• W2343242243 cites W2016783751 @default.
• W2343242243 cites W2019961716 @default.
• W2343242243 cites W2021810546 @default.
• W2343242243 cites W2023949937 @default.
• W2343242243 cites W2027606597 @default.
• W2343242243 cites W2027779917 @default.
• W2343242243 cites W2028452582 @default.
• W2343242243 cites W2028620319 @default.
• W2343242243 cites W2031313830 @default.
• W2343242243 cites W2032781637 @default.
• W2343242243 cites W2033107215 @default.
• W2343242243 cites W2034781878 @default.
• W2343242243 cites W2035968737 @default.
• W2343242243 cites W2038133979 @default.
• W2343242243 cites W2038163496 @default.
• W2343242243 cites W2038468721 @default.
• W2343242243 cites W2046353863 @default.
• W2343242243 cites W2052227340 @default.
• W2343242243 cites W2052471341 @default.
• W2343242243 cites W2053625924 @default.
• W2343242243 cites W2055857902 @default.
• W2343242243 cites W2056145463 @default.
• W2343242243 cites W2067841051 @default.
• W2343242243 cites W2068048197 @default.
• W2343242243 cites W2069013650 @default.
• W2343242243 cites W2070869619 @default.
• W2343242243 cites W2072240385 @default.
• W2343242243 cites W2073706613 @default.
• W2343242243 cites W2074058787 @default.
• W2343242243 cites W2076386951 @default.
• W2343242243 cites W2078179312 @default.
• W2343242243 cites W2080875760 @default.
• W2343242243 cites W2081369737 @default.
• W2343242243 cites W2084281549 @default.
• W2343242243 cites W2084824261 @default.
• W2343242243 cites W2085111073 @default.
• W2343242243 cites W2089849293 @default.
• W2343242243 cites W2092047540 @default.
• W2343242243 cites W2092340487 @default.
• W2343242243 cites W2093931854 @default.
• W2343242243 cites W2094094332 @default.
• W2343242243 cites W2094770594 @default.
• W2343242243 cites W2095218706 @default.
• W2343242243 cites W2096701787 @default.
• W2343242243 cites W2097167248 @default.
• W2343242243 cites W2101826917 @default.
• W2343242243 cites W2102104969 @default.
• W2343242243 cites W2102228853 @default.
• W2343242243 cites W2105859090 @default.
• W2343242243 cites W2108705019 @default.
• W2343242243 cites W2110233921 @default.

• next