Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343285928> ?p ?o ?g. }
- W2343285928 endingPage "785" @default.
- W2343285928 startingPage "754" @default.
- W2343285928 abstract "The exact mechanisms of spontaneous tumor remission or complete response to treatment are phenomena in oncology that are not completely understood. We use a concept from ecology, the Allee effect, to help explain tumor extinction in a model of tumor growth that incorporates feedback regulation of stem cell dynamics, which occurs in many tumor types where certain signaling molecules, such as Wnts, are upregulated. Due to feedback and the Allee effect, a tumor may become extinct spontaneously or after therapy even when the entire tumor has not been eradicated by the end of therapy. We quantify the Allee effect using an 'Allee index' that approximates the area of the basin of attraction for tumor extinction. We show that effectiveness of combination therapy in cancer treatment may occur due to the increased probability that the system will be in the Allee region after combination treatment versus monotherapy. We identify therapies that can attenuate stem cell self-renewal, alter the Allee region and increase its size. We also show that decreased response of tumor cells to growth inhibitors can reduce the size of the Allee region and increase stem cell densities, which may help to explain why this phenomenon is a hallmark of cancer." @default.
- W2343285928 created "2016-06-24" @default.
- W2343285928 creator A5010714351 @default.
- W2343285928 creator A5050122860 @default.
- W2343285928 creator A5059515000 @default.
- W2343285928 date "2016-04-01" @default.
- W2343285928 modified "2023-09-25" @default.
- W2343285928 title "Feedback Regulation in a Cancer Stem Cell Model can Cause an Allee Effect" @default.
- W2343285928 cites W105515719 @default.
- W2343285928 cites W1575185537 @default.
- W2343285928 cites W1965715635 @default.
- W2343285928 cites W1971085650 @default.
- W2343285928 cites W1971740567 @default.
- W2343285928 cites W1973021296 @default.
- W2343285928 cites W1978354618 @default.
- W2343285928 cites W1978480779 @default.
- W2343285928 cites W1980831371 @default.
- W2343285928 cites W1996583924 @default.
- W2343285928 cites W1996715118 @default.
- W2343285928 cites W1998721910 @default.
- W2343285928 cites W1998728654 @default.
- W2343285928 cites W1999316583 @default.
- W2343285928 cites W2006485696 @default.
- W2343285928 cites W2006791068 @default.
- W2343285928 cites W2007614382 @default.
- W2343285928 cites W2009370717 @default.
- W2343285928 cites W2009629707 @default.
- W2343285928 cites W2009852864 @default.
- W2343285928 cites W2016541242 @default.
- W2343285928 cites W2018569307 @default.
- W2343285928 cites W2023351030 @default.
- W2343285928 cites W2026549522 @default.
- W2343285928 cites W2029857102 @default.
- W2343285928 cites W2031524718 @default.
- W2343285928 cites W2034202604 @default.
- W2343285928 cites W2034269086 @default.
- W2343285928 cites W2042108941 @default.
- W2343285928 cites W2045854741 @default.
- W2343285928 cites W2046972425 @default.
- W2343285928 cites W2052576812 @default.
- W2343285928 cites W2057199920 @default.
- W2343285928 cites W2066330900 @default.
- W2343285928 cites W2069825136 @default.
- W2343285928 cites W2070192320 @default.
- W2343285928 cites W2091666474 @default.
- W2343285928 cites W2092271761 @default.
- W2343285928 cites W2097308038 @default.
- W2343285928 cites W2100640599 @default.
- W2343285928 cites W2112933240 @default.
- W2343285928 cites W2113611763 @default.
- W2343285928 cites W2113919377 @default.
- W2343285928 cites W2117692326 @default.
- W2343285928 cites W2118077148 @default.
- W2343285928 cites W2148116965 @default.
- W2343285928 cites W2155507705 @default.
- W2343285928 cites W2157983986 @default.
- W2343285928 cites W2321390672 @default.
- W2343285928 cites W2417625623 @default.
- W2343285928 cites W2598924047 @default.
- W2343285928 cites W4292994524 @default.
- W2343285928 doi "https://doi.org/10.1007/s11538-016-0161-5" @default.
- W2343285928 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4946570" @default.
- W2343285928 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27113934" @default.
- W2343285928 hasPublicationYear "2016" @default.
- W2343285928 type Work @default.
- W2343285928 sameAs 2343285928 @default.
- W2343285928 citedByCount "39" @default.
- W2343285928 countsByYear W23432859282016 @default.
- W2343285928 countsByYear W23432859282017 @default.
- W2343285928 countsByYear W23432859282018 @default.
- W2343285928 countsByYear W23432859282019 @default.
- W2343285928 countsByYear W23432859282020 @default.
- W2343285928 countsByYear W23432859282021 @default.
- W2343285928 countsByYear W23432859282022 @default.
- W2343285928 countsByYear W23432859282023 @default.
- W2343285928 crossrefType "journal-article" @default.
- W2343285928 hasAuthorship W2343285928A5010714351 @default.
- W2343285928 hasAuthorship W2343285928A5050122860 @default.
- W2343285928 hasAuthorship W2343285928A5059515000 @default.
- W2343285928 hasBestOaLocation W23432859282 @default.
- W2343285928 hasConcept C101991246 @default.
- W2343285928 hasConcept C10958125 @default.
- W2343285928 hasConcept C121608353 @default.
- W2343285928 hasConcept C151730666 @default.
- W2343285928 hasConcept C2908647359 @default.
- W2343285928 hasConcept C54355233 @default.
- W2343285928 hasConcept C71924100 @default.
- W2343285928 hasConcept C86803240 @default.
- W2343285928 hasConcept C99454951 @default.
- W2343285928 hasConceptScore W2343285928C101991246 @default.
- W2343285928 hasConceptScore W2343285928C10958125 @default.
- W2343285928 hasConceptScore W2343285928C121608353 @default.
- W2343285928 hasConceptScore W2343285928C151730666 @default.
- W2343285928 hasConceptScore W2343285928C2908647359 @default.
- W2343285928 hasConceptScore W2343285928C54355233 @default.
- W2343285928 hasConceptScore W2343285928C71924100 @default.
- W2343285928 hasConceptScore W2343285928C86803240 @default.
- W2343285928 hasConceptScore W2343285928C99454951 @default.