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- W2343288615 abstract "Abstract Angelica archangelia ( AA ), a traditional herb, has attracted attention as an agent with potential for use in the prevention of chronic skin diseases. This study examined the photoprotective effects of AA on the inhibition of matrix metalloproteinases ( MMP s) and collagen degradation in UVB ‐irradiated normal human dermal fibroblasts. Our results showed that AA markedly blocked collagen degradation by restraining the production of MMP s in UVB ‐exposed fibroblasts. We also investigated the underlying mechanism behind the effects of AA . AA attenuated UVB ‐triggered interleukin‐6 ( IL ‐6) and promoted the expression of transforming growth factor β 1. Application of AA extract (10, 100 μg mL −1 ) significantly diminished UVB ‐induced extracellular signal‐regulated kinase and Jun‐N‐terminal kinase phosphorylation, which consequently reduced phosphorylated c‐Fos and c‐Jun. Our results indicated that AA inhibited the UVB ‐induced expression of MMP s by inhibiting mitogen‐activated protein kinase signaling pathways and activator protein‐1 activation. Our results suggest that AA is a promising botanical agent for use against skin photoaging." @default.
- W2343288615 created "2016-06-24" @default.
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- W2343288615 date "2016-06-03" @default.
- W2343288615 modified "2023-10-18" @default.
- W2343288615 title "<i>Angelica archangelia</i> Prevented Collagen Degradation by Blocking Production of Matrix Metalloproteinases in <scp>UVB</scp>‐exposed Dermal Fibroblasts" @default.
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- W2343288615 doi "https://doi.org/10.1111/php.12595" @default.
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