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- W2343410057 abstract "Objective:To investigate the possible association of C-509T,G-800A,and C-988A single nucleotide polymorphisms(SNP) in the promoter region of transforming growth factor-β1(TGF-β1) gene with the susceptibility to gastric cardia adenocarcinoma(GCA) in a population of Northern China.Methods:Polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP) and polymerase chain reaction amplification refractory mutation system(PCR-ARMS) analysis were used to detect the distribution of SNPs of C-509T,G-800A and C-988A in 214 GCA patients and 298 healthy controls,respectively.The level of TGF-β1 was measured using ELISA and the protein expression of TGF-β1 in tumor tissues and corresponding normal tissues was detected by immunohistochemistry method.Results:The overall genotype and allelotype distributions of C-509T polymorphism of TGF-β1 gene in GCA patients were significantly different from those in healthy controls(P0.05).The subjects with T allelotype had significantly increased risk of developing GCA compared with those with C allelotype carriers [after adjustment for gender,age,and family history of upper digestive tract tumor,the adjusted odds ratio(OR) =1.46,95% confidence interval(CI) =1.05-2.06].Compared with CC genotype,the subjects with CT and TT genotypes had significantly increased risk of developing GCA(adjusted OR=1.84 and 2.02,respectively;95%CI=1.30-2.37 and 1.37-2.59,respectively).The genotype and allelotype distributions of G-800A and C-988A polymorphism of TGF-β1 were not significantly different between GCA patients and healthy controls(P0.05).The serum level of TGF-β1 was significantly higher in GCA patients than that in healthy controls(P0.01) and it was significantly higher in C-509T T allelotype carriers than non C-509T carriers(P0.05).The protein expression of TGF-β1 in GCA tumor tissues was significantly higher than that in corresponding normal tissues(65.5% vs 15.5%,P0.01) and it was higher in C-509T T allelotype carriers than non C-509T carriers(P0.05).Conclusion:T allelotype of C-509T in the promoter region of TGF-β1 may be one of the genetic predisposition genes for developing GCA in Northern China and T allelotype carriers may have increased risk of developing GCA by stimulating the over-expression of TGF-β1." @default.
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- W2343410057 date "2010-01-01" @default.
- W2343410057 modified "2023-09-23" @default.
- W2343410057 title "Correlation of polymorphisms in the promoter region of transforming growth factor β1 with the risk of developing gastric cardia adenocarcinoma" @default.
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