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• W2343460128 abstract "Animal studies suggest that hypertension leads to cardiac tissue hypothyroidism, a condition that can by itself lead to heart failure. We have previously shown that short-term thyroid hormone treatment in Spontaneously Hypertensive Heart Failure (SHHF) rats near heart failure is beneficial. This study tested the hypothesis that therapeutic, long-term T 3 treatment in SHHF rats can prevent or attenuate cardiac dysfunction. Female SHHF rats were treated orally with a physiological T 3 dose (0.04 μg/ml) from 12 to 24 mo of age. Age-matched female SHHF and Wistar-Kyoto rats served as hypertensive and normotensive controls, respectively. SHHF rats had reduced serum free thyroid hormone levels and cardiac tissue T 3 levels, LV dysfunction, and elevated LV collagen content compared with normotensive controls. Restoration of serum and cardiac tissue thyroid hormone levels in T 3 -treated rats was associated with no change in heart rate, but strong trends for improvement in LV systolic function and collagen levels. For instance, end-systolic diameter, fractional shortening, systolic wall stress, and LV collagen levels were no longer significantly different from controls. In conclusion, longstanding hypertension in rats led to chronic low serum and cardiac tissue thyroid hormone levels. Long-term treatment with low-dose T 3 was safe. While cardiac dysfunction could not be completely prevented in the absence of antihypertensive treatment, T 3 may offer additional benefits as an adjunct therapy with possible improvement in diastolic function." @default.
• W2343460128 created "2016-06-24" @default.
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• W2343460128 date "2015-09-15" @default.
• W2343460128 modified "2023-09-27" @default.
• W2343460128 title "Long-term physiological T₃ supplementation in hypertensive heart disease in rats" @default.
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• W2343460128 doi "https://doi.org/10.1152/ajpheart.00431.2015" @default.
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