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• W2343476633 abstract "Sigma factors are an essential part of bacterial gene regulation and have been extensively studied as far as their molecular mechanisms and protein structure are concerned. However, their molecular evolution, especially for the alternative sigma factors, is poorly understood. Here, we analyze the evolutionary forces that have shaped the rpoH sigma factors within the alphaproteobacteria. We found that an ancient duplication gave rise to two major groups of rpoH sigma factors and that after this event horizontal gene transfer (HGT) occurred in rpoH1 group. We also noted that purifying selection has differentially affected distinct parts of the gene; singularly, the gene segment that encodes the region 4.2, which interacts with the -35 motif of the RpoH-dependent genes, has been under relaxed purifying selection. Furthermore, these two major groups are clearly differentiated from one another regarding their promoter selectivity, as rpoH1 is under the transcriptional control of σ70 and σ32, whereas rpoH2 is under the transcriptional control of σ24. Our results suggest a scenario in which HGT, gene loss, variable purifying selection and clear promoter specialization occurred after the ancestral duplication event. More generally, our study offers insights into the molecular evolution of alternative sigma factors and highlights the importance of analyzing not only the coding regions but also the promoter regions." @default.
• W2343476633 created "2016-06-24" @default.
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• W2343476633 date "2016-04-25" @default.
• W2343476633 modified "2023-10-03" @default.
• W2343476633 title "Evolution of a Sigma Factor: An All-In-One of Gene Duplication, Horizontal Gene Transfer, Purifying Selection, and Promoter Differentiation" @default.
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• W2343476633 doi "https://doi.org/10.3389/fmicb.2016.00581" @default.
• W2343476633 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4843759" @default.
• W2343476633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27199915" @default.
• W2343476633 hasPublicationYear "2016" @default.
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