FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343485994> ?p ?o ?g. }

• W2343485994 endingPage "248" @default.
• W2343485994 startingPage "244" @default.
• W2343485994 abstract "The aim was to investigate the role of rabeprazole on the pharmacokinetics (PK) and pharmacodynamics (PD) of metformin. The in vitro inhibition assays on metformin transport were carried out and showed that the half maximal inhibitory concentration (IC50) of rabeprazole on OCT2-mediated metformin transport was 26.0 μM, whereas the IC50 on MATE1-mediated metformin transport inhibition was 4.6 μM. Fifteen healthy Chinese male volunteers were enrolled and given two different doses of metformin plus the co-administration of placebo or rabeprazole. Plasma concentrations of metformin were measured up to 12 h after the second dose. The glucose-lowering effects and the variation of insulin concentrations were evaluated during the oral glucose tolerance test (OGTT). The AUC0–12 of metformin plus rabeprazole were 28,276 ± 5187 ng/ml·h, which was significantly higher than AUC0–12 of metformin plus placebo (24,691 ± 3129 ng/ml·h). Thus, rabeprazole can modestly influence the PK of metformin, suggesting the precaution of using the two drugs together. In OGTTs, rabeprazole decreased the values of AUCinsulin and the maximum insulin concentration. Although rabeprazole showed inhibition effect on OCT2-mediated metformin transport, the glucose-lowering effect of metformin remained the same regardless of its PK changes. Further studies are needed to warrant the effect of rabeprazole on metformin." @default.
• W2343485994 created "2016-06-24" @default.
• W2343485994 creator A5000577927 @default.
• W2343485994 creator A5005160394 @default.
• W2343485994 creator A5017542783 @default.
• W2343485994 creator A5033478608 @default.
• W2343485994 creator A5035886812 @default.
• W2343485994 creator A5040833482 @default.
• W2343485994 creator A5053087783 @default.
• W2343485994 creator A5061036155 @default.
• W2343485994 creator A5075883718 @default.
• W2343485994 date "2016-12-01" @default.
• W2343485994 modified "2023-10-18" @default.
• W2343485994 title "The effects of rabeprazole on metformin pharmacokinetics and pharmacodynamics in Chinese healthy volunteers" @default.
• W2343485994 cites W1533842935 @default.
• W2343485994 cites W1966367806 @default.
• W2343485994 cites W1971574764 @default.
• W2343485994 cites W1998206026 @default.
• W2343485994 cites W2001206326 @default.
• W2343485994 cites W2008031689 @default.
• W2343485994 cites W2020474316 @default.
• W2343485994 cites W2033414137 @default.
• W2343485994 cites W2036919886 @default.
• W2343485994 cites W2044276788 @default.
• W2343485994 cites W2046503553 @default.
• W2343485994 cites W2049865340 @default.
• W2343485994 cites W2060537536 @default.
• W2343485994 cites W2063677427 @default.
• W2343485994 cites W2085689051 @default.
• W2343485994 cites W2086018530 @default.
• W2343485994 cites W2120774442 @default.
• W2343485994 cites W2140345185 @default.
• W2343485994 cites W2146901298 @default.
• W2343485994 cites W2153996274 @default.
• W2343485994 cites W2156244027 @default.
• W2343485994 cites W2166354223 @default.
• W2343485994 cites W2166935017 @default.
• W2343485994 cites W2168343033 @default.
• W2343485994 cites W2196515255 @default.
• W2343485994 cites W2315982688 @default.
• W2343485994 doi "https://doi.org/10.1016/j.jphs.2016.04.016" @default.
• W2343485994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27245553" @default.
• W2343485994 hasPublicationYear "2016" @default.
• W2343485994 type Work @default.
• W2343485994 sameAs 2343485994 @default.
• W2343485994 citedByCount "6" @default.
• W2343485994 countsByYear W23434859942017 @default.
• W2343485994 countsByYear W23434859942019 @default.
• W2343485994 countsByYear W23434859942021 @default.
• W2343485994 countsByYear W23434859942023 @default.
• W2343485994 crossrefType "journal-article" @default.
• W2343485994 hasAuthorship W2343485994A5000577927 @default.
• W2343485994 hasAuthorship W2343485994A5005160394 @default.
• W2343485994 hasAuthorship W2343485994A5017542783 @default.
• W2343485994 hasAuthorship W2343485994A5033478608 @default.
• W2343485994 hasAuthorship W2343485994A5035886812 @default.
• W2343485994 hasAuthorship W2343485994A5040833482 @default.
• W2343485994 hasAuthorship W2343485994A5053087783 @default.
• W2343485994 hasAuthorship W2343485994A5061036155 @default.
• W2343485994 hasAuthorship W2343485994A5075883718 @default.
• W2343485994 hasBestOaLocation W23434859941 @default.
• W2343485994 hasConcept C111113717 @default.
• W2343485994 hasConcept C112705442 @default.
• W2343485994 hasConcept C126322002 @default.
• W2343485994 hasConcept C142724271 @default.
• W2343485994 hasConcept C185592680 @default.
• W2343485994 hasConcept C204787440 @default.
• W2343485994 hasConcept C27081682 @default.
• W2343485994 hasConcept C2777498785 @default.
• W2343485994 hasConcept C2779116819 @default.
• W2343485994 hasConcept C2779306644 @default.
• W2343485994 hasConcept C2780323712 @default.
• W2343485994 hasConcept C71924100 @default.
• W2343485994 hasConcept C98274493 @default.
• W2343485994 hasConceptScore W2343485994C111113717 @default.
• W2343485994 hasConceptScore W2343485994C112705442 @default.
• W2343485994 hasConceptScore W2343485994C126322002 @default.
• W2343485994 hasConceptScore W2343485994C142724271 @default.
• W2343485994 hasConceptScore W2343485994C185592680 @default.
• W2343485994 hasConceptScore W2343485994C204787440 @default.
• W2343485994 hasConceptScore W2343485994C27081682 @default.
• W2343485994 hasConceptScore W2343485994C2777498785 @default.
• W2343485994 hasConceptScore W2343485994C2779116819 @default.
• W2343485994 hasConceptScore W2343485994C2779306644 @default.
• W2343485994 hasConceptScore W2343485994C2780323712 @default.
• W2343485994 hasConceptScore W2343485994C71924100 @default.
• W2343485994 hasConceptScore W2343485994C98274493 @default.
• W2343485994 hasFunder F4320321001 @default.
• W2343485994 hasIssue "4" @default.
• W2343485994 hasLocation W23434859941 @default.
• W2343485994 hasLocation W23434859942 @default.
• W2343485994 hasOpenAccess W2343485994 @default.
• W2343485994 hasPrimaryLocation W23434859941 @default.
• W2343485994 hasRelatedWork W1991037728 @default.
• W2343485994 hasRelatedWork W2000366696 @default.
• W2343485994 hasRelatedWork W2021475052 @default.
• W2343485994 hasRelatedWork W2079444966 @default.
• W2343485994 hasRelatedWork W2159781396 @default.

• next