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• W2343541505 abstract "Systemic lupus erythematosus is an inflammatory autoimmune disease with multi-organ involvement. Central nervous system involvement in systemic lupus erythematosus is common and results in several neurological and psychiatric symptoms that are poorly linked to standard magnetic resonance imaging outcome. Magnetic resonance imaging methods sensitive to tissue microstructural changes, such as diffusion tensor imaging and magnetization transfer imaging, show some correlation with neuropsychiatric systemic lupus erythematosus (NPSLE) symptoms. Histological examination of NPSLE brains reveals presence of cerebral oedema, loss of neurons and myelinated axons, microglial proliferation and reactive astrocytosis, microinfacrts and diffuse ischaemic changes, all of which can affect both diffusion tensor imaging and magnetization transfer imaging in a non-specific manner. Here we investigated the underlying cell-type specific microstructural alterations in the brain of patients with systemic lupus erythematosus with and without a history of central nervous system involvement. We did so combining diffusion tensor imaging with diffusion-weighted magnetic resonance spectroscopy, a powerful tool capable of characterizing cell-specific cytomorphological changes based on diffusion of intracellular metabolites. We used a 7 T magnetic resonance imaging scanner to acquire T 1 -weighted images, diffusion tensor imaging datasets, and single volume diffusion-weighted magnetic resonance spectroscopy data from the anterior body of the corpus callosum of 13 patients with systemic lupus erythematosus with past NPSLE, 16 patients with systemic lupus erythematosus without past NPSLE, and 19 healthy control subjects. Group comparisons were made between patients with systemic lupus erythematosus with/without past NPSLE and healthy controls on diffusion tensor imaging metrics and on diffusion coefficients of three brain metabolites: the exclusively neuronal/axonal N -acetylaspartate, and the predominantly glial creatine + phosphocreatine and choline compounds. In patients with systemic lupus erythematosus with past NPSLE, significantly higher diffusion tensor imaging mean and radial diffusivities were accompanied by a significantly higher intracellular diffusion of total creatine (0.202 ± 0.032 μm 2 /ms, P = 0.018) and total choline (0.142 ± 0.031 μm 2 /ms, P = 0.044) compared to healthy controls (0.171 ± 0.024 μm 2 /ms, 0.124 ± 0.018 μm 2 /ms, respectively). Total N -acetylaspartate, total creatine and total choline diffusion values from all patients with systemic lupus erythematosus correlated positively with systemic lupus erythematosus disease activity index score ( P = 0.033, P = 0.040, P = 0.008, respectively). Our results indicate that intracellular alterations, and in particular changes in glia, as evidenced by increase in the average diffusivities of total choline and total creatine, correlate with systemic lupus erythematosus activity. The higher diffusivity of total creatine and total choline in patients with NPSLE, as well as the positive correlation of these diffusivities with the systemic lupus erythematosus disease activity index are in line with cytomorphological changes in reactive glia, suggesting that the diffusivities of choline compounds and of total creatine are potentially unique markers for glial reactivity in response to inflammation. CNS involvement is common in systemic lupus erythematosus (SLE). Using diffusion-weighted imaging, Ercan et al . explore the link between cell-specific microstructural changes and neuropsychiatric symptoms. Increased diffusivity of predominantly glial metabolites is observed in SLE patients with previous CNS symptoms, and may be a marker for inflammation-related glial reactivity." @default.
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• W2343541505 date "2016-03-11" @default.
• W2343541505 modified "2023-10-17" @default.
• W2343541505 title "Glial and axonal changes in systemic lupus erythematosus measured with diffusion of intracellular metabolites" @default.
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• W2343541505 cites W1993749384 @default.
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• W2343541505 cites W2038259947 @default.
• W2343541505 cites W2038904444 @default.
• W2343541505 cites W2038979894 @default.
• W2343541505 cites W2039214461 @default.
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• W2343541505 doi "https://doi.org/10.1093/brain/aww031" @default.
• W2343541505 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5006250" @default.
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• W2343541505 hasPublicationYear "2016" @default.
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