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- W2343547413 abstract "Clinical guidelines for schizophrenia recommend monotherapy of second-generation antipsychotics (SGAs) for treating patients suffering from schizophrenia, but do not address the issue of how to treat patients with inadequate first-line treatment. The aim of this study is to describe real-word prescription patterns for patients suffering from schizophrenia in Japan. Using data from the Japan Medical Data Center (JMDC) database, a retrospective longitudinal cohort study was conducted, including adults aged from 18 to 65 years with a first prescription of antipsychotic (index date) between January 2009 and September 2013, and diagnosed with schizophrenia around index date. The treatments prescribed in first and second lines were described and treatment duration was estimated using the Kaplan-Meier method. Proportions of patients receiving an add-on treatment, switching or not treated after discontinuation of first-line treatment were estimated. 1,674 patients were included. Mean age of the population was 35.4±11.2 years at index date and 54.5% were females. 82% of these patients received SGA monotherapy as first-line therapy. Among this subgroup, the most frequently prescribed drugs were: olanzapine (27.1%), aripiprazole (27.0%), risperidone (22.1%) and quetiapine (16.3%). 64% of patients reached end of first-line treatment within 6 months, of whom 26.6% had a switch, 11.6% had an augmentation and 61.8% stopped treatment. The median duration of first-line treatment was 3 months. Most frequently prescribed therapies in second line were aripiprazole (23.2%), olanzapine (22.5%), quetiapine (13.7%) and risperidone (9.1%), and 6.3% were antipsychotic combinations. SGA monotherapy was frequently prescribed as first-line treatment, consistently with clinical guidelines. However the duration of first-line therapy is short and the high proportion of patients without treatment may be a cause for concern." @default.
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- W2343547413 date "2015-05-01" @default.
- W2343547413 modified "2023-09-26" @default.
- W2343547413 title "Prescription patterns following First-Line Second-Generation Antipsychotics for patients with Schizophrenia in Japan: an Insurance claims database analysis" @default.
- W2343547413 doi "https://doi.org/10.1016/j.jval.2015.03.752" @default.
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