Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343550349> ?p ?o ?g. }
- W2343550349 endingPage "1368" @default.
- W2343550349 startingPage "1359" @default.
- W2343550349 abstract "In development, embryonic ectoderm differentiates into neuroectoderm and surface ectoderm using poorly understood mechanisms. Here, we show that the transcription factor OVOL2 maintains the transcriptional program of human corneal epithelium cells (CECs), a derivative of the surface ectoderm, and that OVOL2 may regulate the differential transcriptional programs of the two lineages. A functional screen identified OVOL2 as a repressor of mesenchymal genes to maintain CECs. Transduction of OVOL2 with several other transcription factors induced the transcriptional program of CECs in fibroblasts. Moreover, neuroectoderm derivatives were found to express mesenchymal genes, and OVOL2 alone could induce the transcriptional program of CECs in neural progenitors by repressing these genes while activating epithelial genes. Our data suggest that the difference between the transcriptional programs of some neuroectoderm- and surface ectoderm-derivative cells may be regulated in part by a reciprocally repressive mechanism between epithelial and mesenchymal genes, as seen in epithelial-to-mesenchymal transition." @default.
- W2343550349 created "2016-06-24" @default.
- W2343550349 creator A5001574989 @default.
- W2343550349 creator A5014092318 @default.
- W2343550349 creator A5024357491 @default.
- W2343550349 creator A5029687156 @default.
- W2343550349 creator A5048365478 @default.
- W2343550349 creator A5055875696 @default.
- W2343550349 creator A5059193702 @default.
- W2343550349 creator A5066111166 @default.
- W2343550349 creator A5071362768 @default.
- W2343550349 creator A5071659893 @default.
- W2343550349 creator A5071857989 @default.
- W2343550349 creator A5076697611 @default.
- W2343550349 creator A5078459385 @default.
- W2343550349 creator A5084569657 @default.
- W2343550349 creator A5087193515 @default.
- W2343550349 creator A5091504460 @default.
- W2343550349 date "2016-05-01" @default.
- W2343550349 modified "2023-10-15" @default.
- W2343550349 title "OVOL2 Maintains the Transcriptional Program of Human Corneal Epithelium by Suppressing Epithelial-to-Mesenchymal Transition" @default.
- W2343550349 cites W1965436831 @default.
- W2343550349 cites W1982220589 @default.
- W2343550349 cites W1985026339 @default.
- W2343550349 cites W1989269356 @default.
- W2343550349 cites W2012473014 @default.
- W2343550349 cites W2013205740 @default.
- W2343550349 cites W2016360721 @default.
- W2343550349 cites W2018132924 @default.
- W2343550349 cites W2018235103 @default.
- W2343550349 cites W2023238436 @default.
- W2343550349 cites W2024000011 @default.
- W2343550349 cites W2027773301 @default.
- W2343550349 cites W2050280041 @default.
- W2343550349 cites W2054351923 @default.
- W2343550349 cites W2060466734 @default.
- W2343550349 cites W2067733585 @default.
- W2343550349 cites W2087227011 @default.
- W2343550349 cites W2088698936 @default.
- W2343550349 cites W2094129658 @default.
- W2343550349 cites W2095452027 @default.
- W2343550349 cites W2101242815 @default.
- W2343550349 cites W2103919722 @default.
- W2343550349 cites W2108593215 @default.
- W2343550349 cites W2117757143 @default.
- W2343550349 cites W2119226652 @default.
- W2343550349 cites W2134029770 @default.
- W2343550349 cites W2137465688 @default.
- W2343550349 cites W2141392414 @default.
- W2343550349 cites W2146777176 @default.
- W2343550349 cites W2165621629 @default.
- W2343550349 cites W2166686108 @default.
- W2343550349 cites W2168211018 @default.
- W2343550349 doi "https://doi.org/10.1016/j.celrep.2016.04.020" @default.
- W2343550349 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27134177" @default.
- W2343550349 hasPublicationYear "2016" @default.
- W2343550349 type Work @default.
- W2343550349 sameAs 2343550349 @default.
- W2343550349 citedByCount "59" @default.
- W2343550349 countsByYear W23435503492016 @default.
- W2343550349 countsByYear W23435503492017 @default.
- W2343550349 countsByYear W23435503492018 @default.
- W2343550349 countsByYear W23435503492019 @default.
- W2343550349 countsByYear W23435503492020 @default.
- W2343550349 countsByYear W23435503492021 @default.
- W2343550349 countsByYear W23435503492022 @default.
- W2343550349 countsByYear W23435503492023 @default.
- W2343550349 crossrefType "journal-article" @default.
- W2343550349 hasAuthorship W2343550349A5001574989 @default.
- W2343550349 hasAuthorship W2343550349A5014092318 @default.
- W2343550349 hasAuthorship W2343550349A5024357491 @default.
- W2343550349 hasAuthorship W2343550349A5029687156 @default.
- W2343550349 hasAuthorship W2343550349A5048365478 @default.
- W2343550349 hasAuthorship W2343550349A5055875696 @default.
- W2343550349 hasAuthorship W2343550349A5059193702 @default.
- W2343550349 hasAuthorship W2343550349A5066111166 @default.
- W2343550349 hasAuthorship W2343550349A5071362768 @default.
- W2343550349 hasAuthorship W2343550349A5071659893 @default.
- W2343550349 hasAuthorship W2343550349A5071857989 @default.
- W2343550349 hasAuthorship W2343550349A5076697611 @default.
- W2343550349 hasAuthorship W2343550349A5078459385 @default.
- W2343550349 hasAuthorship W2343550349A5084569657 @default.
- W2343550349 hasAuthorship W2343550349A5087193515 @default.
- W2343550349 hasAuthorship W2343550349A5091504460 @default.
- W2343550349 hasBestOaLocation W23435503491 @default.
- W2343550349 hasConcept C104317684 @default.
- W2343550349 hasConcept C127561419 @default.
- W2343550349 hasConcept C135073763 @default.
- W2343550349 hasConcept C145103041 @default.
- W2343550349 hasConcept C198826908 @default.
- W2343550349 hasConcept C27153228 @default.
- W2343550349 hasConcept C2779329299 @default.
- W2343550349 hasConcept C2780915607 @default.
- W2343550349 hasConcept C54355233 @default.
- W2343550349 hasConcept C76419328 @default.
- W2343550349 hasConcept C86339819 @default.
- W2343550349 hasConcept C86803240 @default.
- W2343550349 hasConcept C95444343 @default.