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• W2343577498 abstract "Unlike other members of polycomb group genes, EZH1 has been shown to positively associate with active transcription in the genome-wide scale. However, the underlying mechanisms still remain elusive. Here we report that EZH1 physically interacts with UXT, one small chaperon-like transcription co-activator. UXT specifically interacts with EZH1 and SUZ12, but not EED. Similar to UXT, RNA interference of EZH1 or SUZ12 in the cell impairs the transcriptional activation of NF-κB target genes induced by TNFα. EZH1 deficiency also increases TNFα-induced cell death. Interestingly, chromatin immunoprecipitation and the following next generation sequencing analysis show that H3K27 mono-, di- and trimethylation on NF-κB target genes are not affected in EZH1 or UXT deficient cells. EZH1 does not affect RELA/p65 translocation from cytosol to nuclear either. Instead, EZH1 and SUZ12 regulate the recruitment of RELA/p65 and RNA Pol II to target genes. Taken together, our study found that EZH1 and SUZ12 as positive regulators for NF-κB signaling and demonstrated the underlying mechanism that EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus." @default.
• W2343577498 created "2016-06-24" @default.
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• W2343577498 date "2016-01-01" @default.
• W2343577498 modified "2023-10-13" @default.
• W2343577498 title "EZH1/SUZ12 complex positively regulates the transcription of NF-κB target genes <i>via</i> interaction with UXT" @default.
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• W2343577498 doi "https://doi.org/10.1242/jcs.185546" @default.
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