Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343695087> ?p ?o ?g. }
- W2343695087 endingPage "4222" @default.
- W2343695087 startingPage "4214" @default.
- W2343695087 abstract "Genome-wide datasets measuring nascent RNA have revealed that active human promoters frequently display divergent transcription, generating a stable mRNA in the forward direction toward the gene and a typically unstable one in the reverse direction away from the gene. Recent work has shown that these transcripts originate from two distinct core promoters within a single nucleosome-free region (NFR). Different levels of forward and reverse activity lead to a wide range of directionality for promoter NFRs. Importantly, directionality is also reflected in the epigenetic modifications of nucleosomes immediately adjacent to the NFR. Here, we review the current literature pertaining to divergent transcription from promoter NFRs and its association with combinatorial histone post-translational modifications, or chromatin states, on upstream and downstream nucleosomes. Finally, we discuss several models to interpret the directionality of promoter chromatin states." @default.
- W2343695087 created "2016-06-24" @default.
- W2343695087 creator A5000077668 @default.
- W2343695087 creator A5046221130 @default.
- W2343695087 creator A5066684109 @default.
- W2343695087 creator A5089817227 @default.
- W2343695087 date "2016-05-11" @default.
- W2343695087 modified "2023-10-10" @default.
- W2343695087 title "Divergent transcription and epigenetic directionality of human promoters" @default.
- W2343695087 cites W1171540079 @default.
- W2343695087 cites W1549155795 @default.
- W2343695087 cites W1783475379 @default.
- W2343695087 cites W1862136016 @default.
- W2343695087 cites W1964963969 @default.
- W2343695087 cites W1974595249 @default.
- W2343695087 cites W1989419347 @default.
- W2343695087 cites W1998871958 @default.
- W2343695087 cites W1999808854 @default.
- W2343695087 cites W2004190259 @default.
- W2343695087 cites W2007844697 @default.
- W2343695087 cites W2008616402 @default.
- W2343695087 cites W2008865929 @default.
- W2343695087 cites W2010291571 @default.
- W2343695087 cites W2015416439 @default.
- W2343695087 cites W2018363492 @default.
- W2343695087 cites W2021678907 @default.
- W2343695087 cites W2026027175 @default.
- W2343695087 cites W2032812076 @default.
- W2343695087 cites W2037686178 @default.
- W2343695087 cites W2038533423 @default.
- W2343695087 cites W2039269859 @default.
- W2343695087 cites W2053323016 @default.
- W2343695087 cites W2067058481 @default.
- W2343695087 cites W2068379897 @default.
- W2343695087 cites W2072152932 @default.
- W2343695087 cites W2075560058 @default.
- W2343695087 cites W2076825429 @default.
- W2343695087 cites W2080900647 @default.
- W2343695087 cites W2091452413 @default.
- W2343695087 cites W2091533196 @default.
- W2343695087 cites W2097565373 @default.
- W2343695087 cites W2101102182 @default.
- W2343695087 cites W2110010240 @default.
- W2343695087 cites W2115948084 @default.
- W2343695087 cites W2120100277 @default.
- W2343695087 cites W2121910267 @default.
- W2343695087 cites W2123404806 @default.
- W2343695087 cites W2124042578 @default.
- W2343695087 cites W2124343649 @default.
- W2343695087 cites W2125235548 @default.
- W2343695087 cites W2127081697 @default.
- W2343695087 cites W2129214044 @default.
- W2343695087 cites W2129917811 @default.
- W2343695087 cites W2131930552 @default.
- W2343695087 cites W2133727333 @default.
- W2343695087 cites W2148503087 @default.
- W2343695087 cites W2161585925 @default.
- W2343695087 cites W2161671616 @default.
- W2343695087 cites W2167315449 @default.
- W2343695087 cites W2168602111 @default.
- W2343695087 cites W2171525715 @default.
- W2343695087 cites W2175867816 @default.
- W2343695087 cites W2198371822 @default.
- W2343695087 cites W2221136395 @default.
- W2343695087 cites W4230875896 @default.
- W2343695087 doi "https://doi.org/10.1111/febs.13747" @default.
- W2343695087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27115538" @default.
- W2343695087 hasPublicationYear "2016" @default.
- W2343695087 type Work @default.
- W2343695087 sameAs 2343695087 @default.
- W2343695087 citedByCount "22" @default.
- W2343695087 countsByYear W23436950872017 @default.
- W2343695087 countsByYear W23436950872018 @default.
- W2343695087 countsByYear W23436950872019 @default.
- W2343695087 countsByYear W23436950872020 @default.
- W2343695087 countsByYear W23436950872021 @default.
- W2343695087 countsByYear W23436950872022 @default.
- W2343695087 countsByYear W23436950872023 @default.
- W2343695087 crossrefType "journal-article" @default.
- W2343695087 hasAuthorship W2343695087A5000077668 @default.
- W2343695087 hasAuthorship W2343695087A5046221130 @default.
- W2343695087 hasAuthorship W2343695087A5066684109 @default.
- W2343695087 hasAuthorship W2343695087A5089817227 @default.
- W2343695087 hasBestOaLocation W23436950871 @default.
- W2343695087 hasConcept C101762097 @default.
- W2343695087 hasConcept C104317684 @default.
- W2343695087 hasConcept C138885662 @default.
- W2343695087 hasConcept C141231307 @default.
- W2343695087 hasConcept C150194340 @default.
- W2343695087 hasConcept C179926584 @default.
- W2343695087 hasConcept C197077220 @default.
- W2343695087 hasConcept C29648211 @default.
- W2343695087 hasConcept C41091548 @default.
- W2343695087 hasConcept C41895202 @default.
- W2343695087 hasConcept C54355233 @default.
- W2343695087 hasConcept C64927066 @default.
- W2343695087 hasConcept C70721500 @default.
- W2343695087 hasConcept C83640560 @default.