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- W2343803286 abstract "Serum amyloid P-component (SAP) contributes to host defense and prevents fibrosis. Macrophages are the most abundant inflammatory cell type in atherosclerotic plaques. In the present study, using 3 H-cholesterol-labeled counting radioactivity assay, we demonstrated that the apoAI-mediated cholesterol efflux in RAW264.7 macrophages was increased by SAP treatment in a time- and dose-dependent manner. We analyzed global gene expression changes upon SAP treatment using RNA sequencing. As a result, a total of 175 differentially expressed genes were identified, of which 134 genes were downregulated and 41 genes were upregulated in SAP treated cells compared to control cells. Quantitative RT-PCR analysis confirmed decreased expression of 5 genes and an increase in expression of 1 gene upon SAP treatment. Gene ontology analysis showed that genes involved in response to stimulus were significantly enriched in differentially expressed genes. Beyond protein-coding genes, we also identified 8 differentially expressed long noncoding RNAs. Our study may provide new insights into mechanisms underlying the functional role of SAP in macrophages." @default.
- W2343803286 created "2016-06-24" @default.
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- W2343803286 date "2016-01-01" @default.
- W2343803286 modified "2023-10-17" @default.
- W2343803286 title "The Impact of Serum Amyloid P-Component on Gene Expression in RAW264.7 Mouse Macrophages" @default.
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- W2343803286 doi "https://doi.org/10.1155/2016/9380290" @default.
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