Matches in SemOpenAlex for { <https://semopenalex.org/work/W2343843045> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W2343843045 abstract "This dissertation is divided into three parts. The first section is concerned with protein synthesis in cellfreesystems from reticulocytes. The sub-cellular reticulocyte fractions,reagents, etc. have been examined for the presence of traces of ribonuclease,using. an assay based upon the loss of infectivity of RNAfran bacteriophage MS2. This assay is sensitive to 5 x 10-7 γ RNase/ml.In addition, the loss of synthetic capacity of an 80S ribosome on dissociationhas been studied, and can be attributed to loss of messengerRNA when the monomer is separated into subunits. The presence ofribonuclease has been shown to be a major cause of polyribosome disintegrationduring cell-free protein synthesis. The second section concerns the changes in ribosomes and polyribosomeswhich occur during the maturation of a reticulocyte into anerythrocyte. With increasing age, the cells lose a large proportion ofthe ribonucleoprotein, but the percentage of ribosomes present as polyribosomesis only slightly altered. The loss of hemoglobin synthesison maturation is probably due to both the loss of total ribosomesand to the lessened specific activity of the polyribosomes. The third section contains analytical ultracentrifugation dataon 80S ribosomes, polyribosomes, and ribosomal RNA from reticulocytes.The 60s and 40s subunits, obtained by dissociation of the 80s particlewith inorganic pyrophosphate, were also studied. The RNA from reticulocyteribosomes has been examined under a variety of denaturing conditions,including dimethyl sulfoxide treatment, formaldehyde reaction and thermaldenaturation. From these studies we can conclude that the 28S and16S RNA's are single polynucleotide chains and are not made up ofsmaller RNA subunits hydrogen-bonded together." @default.
- W2343843045 created "2016-06-24" @default.
- W2343843045 creator A5078794739 @default.
- W2343843045 date "1966-01-01" @default.
- W2343843045 modified "2023-09-27" @default.
- W2343843045 title "Studies on rabbit reticulocyte ribosomes and polyribosomes and their relation to hemoglobin synthesis" @default.
- W2343843045 doi "https://doi.org/10.7907/h4ba-4m16." @default.
- W2343843045 hasPublicationYear "1966" @default.
- W2343843045 type Work @default.
- W2343843045 sameAs 2343843045 @default.
- W2343843045 citedByCount "0" @default.
- W2343843045 crossrefType "dissertation" @default.
- W2343843045 hasAuthorship W2343843045A5078794739 @default.
- W2343843045 hasConcept C104317684 @default.
- W2343843045 hasConcept C10879258 @default.
- W2343843045 hasConcept C129194359 @default.
- W2343843045 hasConcept C153911025 @default.
- W2343843045 hasConcept C185592680 @default.
- W2343843045 hasConcept C2778403015 @default.
- W2343843045 hasConcept C2778976237 @default.
- W2343843045 hasConcept C3675279 @default.
- W2343843045 hasConcept C55493867 @default.
- W2343843045 hasConcept C65666806 @default.
- W2343843045 hasConcept C67705224 @default.
- W2343843045 hasConcept C67905577 @default.
- W2343843045 hasConcept C86803240 @default.
- W2343843045 hasConcept C88478588 @default.
- W2343843045 hasConceptScore W2343843045C104317684 @default.
- W2343843045 hasConceptScore W2343843045C10879258 @default.
- W2343843045 hasConceptScore W2343843045C129194359 @default.
- W2343843045 hasConceptScore W2343843045C153911025 @default.
- W2343843045 hasConceptScore W2343843045C185592680 @default.
- W2343843045 hasConceptScore W2343843045C2778403015 @default.
- W2343843045 hasConceptScore W2343843045C2778976237 @default.
- W2343843045 hasConceptScore W2343843045C3675279 @default.
- W2343843045 hasConceptScore W2343843045C55493867 @default.
- W2343843045 hasConceptScore W2343843045C65666806 @default.
- W2343843045 hasConceptScore W2343843045C67705224 @default.
- W2343843045 hasConceptScore W2343843045C67905577 @default.
- W2343843045 hasConceptScore W2343843045C86803240 @default.
- W2343843045 hasConceptScore W2343843045C88478588 @default.
- W2343843045 hasLocation W23438430451 @default.
- W2343843045 hasOpenAccess W2343843045 @default.
- W2343843045 hasPrimaryLocation W23438430451 @default.
- W2343843045 hasRelatedWork W1546158790 @default.
- W2343843045 hasRelatedWork W1593370118 @default.
- W2343843045 hasRelatedWork W1968129707 @default.
- W2343843045 hasRelatedWork W1977825734 @default.
- W2343843045 hasRelatedWork W1981669520 @default.
- W2343843045 hasRelatedWork W1999751181 @default.
- W2343843045 hasRelatedWork W2023276597 @default.
- W2343843045 hasRelatedWork W2025421264 @default.
- W2343843045 hasRelatedWork W2027377708 @default.
- W2343843045 hasRelatedWork W2030014218 @default.
- W2343843045 hasRelatedWork W2036926259 @default.
- W2343843045 hasRelatedWork W2049130973 @default.
- W2343843045 hasRelatedWork W2050214317 @default.
- W2343843045 hasRelatedWork W2053724338 @default.
- W2343843045 hasRelatedWork W2072804179 @default.
- W2343843045 hasRelatedWork W2075808635 @default.
- W2343843045 hasRelatedWork W2089923116 @default.
- W2343843045 hasRelatedWork W2139164237 @default.
- W2343843045 hasRelatedWork W2157621864 @default.
- W2343843045 hasRelatedWork W1970876104 @default.
- W2343843045 isParatext "false" @default.
- W2343843045 isRetracted "false" @default.
- W2343843045 magId "2343843045" @default.
- W2343843045 workType "dissertation" @default.