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• W2343956642 abstract "Hypoxia is a physiologic condition which is a component of many disease processes. Hypoxia can be mediated by low inspired oxygen, lung disease or organ ischemia. Although, in general, the delivery of oxygen to tissue has sufficient excess capacity to compensate for a wide range of demand (luxury perfusion), a marked deficiency of intracellular oxygen results in immediate tissue dysfunction. Prolonged hypoxia is the prevalent cause of irreversible injury in all mammalian tissues (Cotran et al., 1989). Hypoxia plays a role in the pathogenesis of stroke (for review see Hossmann, 1994), cardiac disease (Rumsey et al., 1994), cancer (for review see Adams, 1990), ocular disease (for example see Flammer, 1994), renal disease (Brezis and Rosen, 1995), rheumatoid arthritis (for review see Edmonds et al., 1995) and wound healing (for review see Hunt, 1988), among others. In many diseases, including cancer, the presence of hypoxia decreases the effectiveness of therapy and signals a poor prognosis (Brizel et al, 1996; Hockel et al., 1993)." @default.
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• W2343956642 date "1997-01-01" @default.
• W2343956642 modified "2023-09-27" @default.
• W2343956642 title "Imaging Hypoxia in Diseased Tissues" @default.
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• W2343956642 doi "https://doi.org/10.1007/978-1-4615-5399-1_84" @default.
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