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- W2344011235 abstract "The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs. Of particular interest, DGCR8 controls the stability of mature small nucleolar RNA (snoRNA) transcripts independently of Drosha, suggesting the existence of alternative DGCR8 complex(es) with other nucleases to process a variety of cellular RNAs. Here, we found that DGCR8 copurifies with subunits of the nuclear exosome, preferentially associating with its hRRP6-containing nucleolar form. Importantly, we demonstrate that DGCR8 is essential for the recruitment of the exosome to snoRNAs and to human telomerase RNA. In addition, we show that the DGCR8/exosome complex controls the stability of the human telomerase RNA component (hTR/TERC). Altogether, these data suggest that DGCR8 acts as an adaptor to recruit the exosome complex to structured RNAs and induce their degradation." @default.
- W2344011235 created "2016-06-24" @default.
- W2344011235 creator A5055339151 @default.
- W2344011235 date "2015-12-01" @default.
- W2344011235 modified "2023-09-23" @default.
- W2344011235 title "Knowledge of health outcomes generated by drugs in the real world: Temporary fashion or real need?" @default.
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- W2344011235 doi "https://doi.org/10.1016/j.medcle.2016.04.022" @default.
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