Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344032069> ?p ?o ?g. }
- W2344032069 endingPage "5304" @default.
- W2344032069 startingPage "5294" @default.
- W2344032069 abstract "The presence of synthetic glucocorticoids within the aquatic environment has been highlighted as a potential environmental concern as they may mimic the role of endogenous glucocorticoids during vertebrate ontogeny. Prednisolone is a commonly prescribed synthetic glucocorticoid which has been repeatedly detected in the environment. This study investigated the impact of environmentally relevant concentrations of prednisolone (0.1, 1, and 10 μg/L) during zebrafish embryogenesis using physiological and behavioral end points which are known to be mediated by endogenous glucocorticoids. The frequency of spontaneous muscle contractions (24 hpf) was significantly reduced by prednisolone and 0.1 μg/L increased the distance embryos swam in response to a mechanosensory stimulus (48 hpf). The percentage of embryos hatched significantly increased following prednisolone treatment (1 and 10 μg/L), while growth and mortality were unaffected. The onset of heart contraction was differentially affected by prednisolone while heart rate and oxygen consumption both increased significantly throughout embryogenesis. No substantial effect on the axial musculature was observed. Morphological changes to the lower jaw were detected at 96 hpf in response to 1 μg/L of prednisolone. Several parameters of swim behavior were also significantly affected. Environmentally relevant concentrations of prednisolone therefore alter early zebrafish ontogeny and significantly affect embryo behavior." @default.
- W2344032069 created "2016-06-24" @default.
- W2344032069 creator A5015034880 @default.
- W2344032069 creator A5030855546 @default.
- W2344032069 creator A5042249193 @default.
- W2344032069 date "2016-04-28" @default.
- W2344032069 modified "2023-10-17" @default.
- W2344032069 title "Physiological and Behavioral Effects of Exposure to Environmentally Relevant Concentrations of Prednisolone During Zebrafish (<i>Danio rerio</i>) Embryogenesis" @default.
- W2344032069 cites W1602000534 @default.
- W2344032069 cites W1901879217 @default.
- W2344032069 cites W1963485403 @default.
- W2344032069 cites W1971793821 @default.
- W2344032069 cites W1975284976 @default.
- W2344032069 cites W1977917688 @default.
- W2344032069 cites W1983636756 @default.
- W2344032069 cites W1986800937 @default.
- W2344032069 cites W1993926520 @default.
- W2344032069 cites W1998467104 @default.
- W2344032069 cites W1998643629 @default.
- W2344032069 cites W2004563925 @default.
- W2344032069 cites W2006136808 @default.
- W2344032069 cites W2024033014 @default.
- W2344032069 cites W2024495965 @default.
- W2344032069 cites W2026530704 @default.
- W2344032069 cites W2028010926 @default.
- W2344032069 cites W2028217891 @default.
- W2344032069 cites W2033166635 @default.
- W2344032069 cites W2035340393 @default.
- W2344032069 cites W2043909105 @default.
- W2344032069 cites W2045156934 @default.
- W2344032069 cites W2047035225 @default.
- W2344032069 cites W2051872859 @default.
- W2344032069 cites W2063337445 @default.
- W2344032069 cites W2066147278 @default.
- W2344032069 cites W2069156135 @default.
- W2344032069 cites W2069667065 @default.
- W2344032069 cites W2070040120 @default.
- W2344032069 cites W2070814990 @default.
- W2344032069 cites W2074053057 @default.
- W2344032069 cites W2075432396 @default.
- W2344032069 cites W2076912174 @default.
- W2344032069 cites W2084661609 @default.
- W2344032069 cites W2086193647 @default.
- W2344032069 cites W2086951855 @default.
- W2344032069 cites W2089247555 @default.
- W2344032069 cites W2091570417 @default.
- W2344032069 cites W2099445531 @default.
- W2344032069 cites W2104784626 @default.
- W2344032069 cites W2109458697 @default.
- W2344032069 cites W2111274663 @default.
- W2344032069 cites W2113343190 @default.
- W2344032069 cites W2116082328 @default.
- W2344032069 cites W2116751183 @default.
- W2344032069 cites W2116948661 @default.
- W2344032069 cites W2118345887 @default.
- W2344032069 cites W2120493475 @default.
- W2344032069 cites W2121155069 @default.
- W2344032069 cites W2122920636 @default.
- W2344032069 cites W2139818147 @default.
- W2344032069 cites W2141333511 @default.
- W2344032069 cites W2145334570 @default.
- W2344032069 cites W2147984826 @default.
- W2344032069 cites W2148950323 @default.
- W2344032069 cites W2148989249 @default.
- W2344032069 cites W2150337400 @default.
- W2344032069 cites W2150781292 @default.
- W2344032069 cites W2152770225 @default.
- W2344032069 cites W2153314004 @default.
- W2344032069 cites W2156720889 @default.
- W2344032069 cites W2158343977 @default.
- W2344032069 cites W2160475782 @default.
- W2344032069 cites W2183044194 @default.
- W2344032069 cites W2209301489 @default.
- W2344032069 cites W2254920228 @default.
- W2344032069 cites W2327251869 @default.
- W2344032069 cites W297083069 @default.
- W2344032069 cites W4232407441 @default.
- W2344032069 cites W4237506555 @default.
- W2344032069 doi "https://doi.org/10.1021/acs.est.6b00276" @default.
- W2344032069 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27120978" @default.
- W2344032069 hasPublicationYear "2016" @default.
- W2344032069 type Work @default.
- W2344032069 sameAs 2344032069 @default.
- W2344032069 citedByCount "36" @default.
- W2344032069 countsByYear W23440320692016 @default.
- W2344032069 countsByYear W23440320692017 @default.
- W2344032069 countsByYear W23440320692018 @default.
- W2344032069 countsByYear W23440320692019 @default.
- W2344032069 countsByYear W23440320692020 @default.
- W2344032069 countsByYear W23440320692021 @default.
- W2344032069 countsByYear W23440320692022 @default.
- W2344032069 countsByYear W23440320692023 @default.
- W2344032069 crossrefType "journal-article" @default.
- W2344032069 hasAuthorship W2344032069A5015034880 @default.
- W2344032069 hasAuthorship W2344032069A5030855546 @default.
- W2344032069 hasAuthorship W2344032069A5042249193 @default.
- W2344032069 hasBestOaLocation W23440320692 @default.
- W2344032069 hasConcept C104317684 @default.