Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344038501> ?p ?o ?g. }
- W2344038501 abstract "Ubiquitin is essential for eukaryotic life and varies in only 3 amino acid positions between yeast and humans. However, recent deep sequencing studies indicate that ubiquitin is highly tolerant to single mutations. We hypothesized that this tolerance would be reduced by chemically induced physiologic perturbations. To test this hypothesis, a class of first year UCSF graduate students employed deep mutational scanning to determine the fitness landscape of all possible single residue mutations in the presence of five different small molecule perturbations. These perturbations uncover 'shared sensitized positions' localized to areas around the hydrophobic patch and the C-terminus. In addition, we identified perturbation specific effects such as a sensitization of His68 in HU and a tolerance to mutation at Lys63 in DTT. Our data show how chemical stresses can reduce buffering effects in the ubiquitin proteasome system. Finally, this study demonstrates the potential of lab-based interdisciplinary graduate curriculum." @default.
- W2344038501 created "2016-06-24" @default.
- W2344038501 creator A5000906927 @default.
- W2344038501 creator A5001475448 @default.
- W2344038501 creator A5005112936 @default.
- W2344038501 creator A5009279318 @default.
- W2344038501 creator A5010039785 @default.
- W2344038501 creator A5013333355 @default.
- W2344038501 creator A5013481289 @default.
- W2344038501 creator A5017505330 @default.
- W2344038501 creator A5019101990 @default.
- W2344038501 creator A5019227886 @default.
- W2344038501 creator A5021467895 @default.
- W2344038501 creator A5026900391 @default.
- W2344038501 creator A5033002839 @default.
- W2344038501 creator A5035691699 @default.
- W2344038501 creator A5037404285 @default.
- W2344038501 creator A5039233775 @default.
- W2344038501 creator A5039824565 @default.
- W2344038501 creator A5041139912 @default.
- W2344038501 creator A5041346250 @default.
- W2344038501 creator A5043906636 @default.
- W2344038501 creator A5046372751 @default.
- W2344038501 creator A5046478796 @default.
- W2344038501 creator A5048087410 @default.
- W2344038501 creator A5048434672 @default.
- W2344038501 creator A5051355898 @default.
- W2344038501 creator A5053031659 @default.
- W2344038501 creator A5058478767 @default.
- W2344038501 creator A5060336546 @default.
- W2344038501 creator A5060481418 @default.
- W2344038501 creator A5061753138 @default.
- W2344038501 creator A5062623278 @default.
- W2344038501 creator A5063956571 @default.
- W2344038501 creator A5070291410 @default.
- W2344038501 creator A5079215322 @default.
- W2344038501 creator A5079726555 @default.
- W2344038501 creator A5080200934 @default.
- W2344038501 creator A5083991944 @default.
- W2344038501 creator A5088692545 @default.
- W2344038501 creator A5090471536 @default.
- W2344038501 creator A5091707970 @default.
- W2344038501 creator A5091824858 @default.
- W2344038501 date "2016-04-25" @default.
- W2344038501 modified "2023-10-14" @default.
- W2344038501 title "Determination of ubiquitin fitness landscapes under different chemical stresses in a classroom setting" @default.
- W2344038501 cites W1483456869 @default.
- W2344038501 cites W1540649941 @default.
- W2344038501 cites W1552511499 @default.
- W2344038501 cites W1575978940 @default.
- W2344038501 cites W1760278939 @default.
- W2344038501 cites W1949401050 @default.
- W2344038501 cites W1978110215 @default.
- W2344038501 cites W1995857416 @default.
- W2344038501 cites W1997477098 @default.
- W2344038501 cites W1999746307 @default.
- W2344038501 cites W2002456037 @default.
- W2344038501 cites W2008744347 @default.
- W2344038501 cites W2008775082 @default.
- W2344038501 cites W2011368229 @default.
- W2344038501 cites W2013339424 @default.
- W2344038501 cites W2031174268 @default.
- W2344038501 cites W2035094622 @default.
- W2344038501 cites W2041380027 @default.
- W2344038501 cites W2042750808 @default.
- W2344038501 cites W2048450765 @default.
- W2344038501 cites W2048945712 @default.
- W2344038501 cites W2050630298 @default.
- W2344038501 cites W2051452587 @default.
- W2344038501 cites W2054661608 @default.
- W2344038501 cites W2059781917 @default.
- W2344038501 cites W2062739292 @default.
- W2344038501 cites W2065709249 @default.
- W2344038501 cites W2066859686 @default.
- W2344038501 cites W2069494008 @default.
- W2344038501 cites W2073946289 @default.
- W2344038501 cites W2076159058 @default.
- W2344038501 cites W2077301629 @default.
- W2344038501 cites W2080553628 @default.
- W2344038501 cites W2082788676 @default.
- W2344038501 cites W2094223039 @default.
- W2344038501 cites W2094460693 @default.
- W2344038501 cites W2097453957 @default.
- W2344038501 cites W2100691289 @default.
- W2344038501 cites W2103151604 @default.
- W2344038501 cites W2107409328 @default.
- W2344038501 cites W2122680286 @default.
- W2344038501 cites W2131587773 @default.
- W2344038501 cites W2132535068 @default.
- W2344038501 cites W2133053859 @default.
- W2344038501 cites W2137683543 @default.
- W2344038501 cites W2147286372 @default.
- W2344038501 cites W2147917253 @default.
- W2344038501 cites W2150192011 @default.
- W2344038501 cites W2153457180 @default.
- W2344038501 cites W2156576736 @default.
- W2344038501 cites W2158131232 @default.
- W2344038501 cites W2160330189 @default.
- W2344038501 cites W2163581448 @default.
- W2344038501 cites W2164037809 @default.