Matches in SemOpenAlex for { <https://semopenalex.org/work/W2344050635> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2344050635 endingPage "8111" @default.
- W2344050635 startingPage "8111" @default.
- W2344050635 abstract "8111 Background: Hyperphosphorylated paratarg-7 (pP-7) is a frequent target of paraproteins in Caucasian patients with MGUS/MM (Preuss et al. Int J Cancer. 2009; 125:656-61). Carriers of pP-7 have an 8-times increased risk to develop IgA/IgG-MGUS and multiple myeloma (Grass et al., Lancet Oncology. 2009; 10:950-956) and a 6.5 times increased risk to develop IgM-MGUS and Waldenström's macroglobulinemia (Grass et al., Blood. 2009;114:1513s). Analysis of affected families showed that pP-7 is inherited in a dominant fashion. Thus pP-7 is the first molecularly defined autosomal-dominant risk factor for any hematological neoplasm. Because of its autosomal-dominant inheritance we investigated the prevalence of pP-7 carrier state in a Japanese population where the frequency of MGUS/MM is lower than in Europe, and compared it with that of a Caucasian population of MGUS/MM patients and healthy controls. Methods: Peripheral blood from 252 Caucasian patients with MGUS/MM and 200 healthy blood donors was analyzed for pP-7 carrier state by isoelectric focussing and for pP-7 specific antibodies by ELISA and compared with 59 Japanese MGUS/MM patients and 178 healthy Japanese controls. Results: 35/252 (13.9%) of German, but only 2/59 (3.4%) of Japanese IgA/IgG MGUS/MM patients had a pP-7 specific paraprotein (p=0.025; c2-test). The prevalence of healthy pP-7 carriers in the German population was 4/200 (2.0%), while it was only 1/178 (0.6%) in the Japanese population (p=0.376; Fisher's exact test). The relative risk for pP-7 carriers to develop MGUS/MM has an odds ratio of 7.9 (p<0.001) in the Caucasian population, while it is 6.2-fold (p=0.139) in the Japanese population. Conclusions: The fraction of pP-7 carriers with a pP-7 specific paraprotein among the patients with MGUS/MM is higher among Caucasians than Japanese patients. Nevertheless, pP-7 carrier state is associated with a similarly increased risk to develop MGUS/MM in both populations. pP-7 is the risk factor with by far the highest odds ratio to develop IgA/IgG-MGUS and multiple myeloma known to date in both ethnic groups. No significant financial relationships to disclose." @default.
- W2344050635 created "2016-06-24" @default.
- W2344050635 creator A5008005637 @default.
- W2344050635 creator A5029434790 @default.
- W2344050635 creator A5030025370 @default.
- W2344050635 creator A5030213509 @default.
- W2344050635 creator A5039483120 @default.
- W2344050635 creator A5046545300 @default.
- W2344050635 creator A5069415812 @default.
- W2344050635 creator A5071330506 @default.
- W2344050635 creator A5078852881 @default.
- W2344050635 date "2010-05-20" @default.
- W2344050635 modified "2023-09-26" @default.
- W2344050635 title "Association of hyperphosphorylated paratarg-7, the first autosomal-dominantly inherited risk factor for hematological neoplasms, with MGUS and multiple myeloma in different ethnic groups." @default.
- W2344050635 doi "https://doi.org/10.1200/jco.2010.28.15_suppl.8111" @default.
- W2344050635 hasPublicationYear "2010" @default.
- W2344050635 type Work @default.
- W2344050635 sameAs 2344050635 @default.
- W2344050635 citedByCount "0" @default.
- W2344050635 crossrefType "journal-article" @default.
- W2344050635 hasAuthorship W2344050635A5008005637 @default.
- W2344050635 hasAuthorship W2344050635A5029434790 @default.
- W2344050635 hasAuthorship W2344050635A5030025370 @default.
- W2344050635 hasAuthorship W2344050635A5030213509 @default.
- W2344050635 hasAuthorship W2344050635A5039483120 @default.
- W2344050635 hasAuthorship W2344050635A5046545300 @default.
- W2344050635 hasAuthorship W2344050635A5069415812 @default.
- W2344050635 hasAuthorship W2344050635A5071330506 @default.
- W2344050635 hasAuthorship W2344050635A5078852881 @default.
- W2344050635 hasConcept C121608353 @default.
- W2344050635 hasConcept C126322002 @default.
- W2344050635 hasConcept C143998085 @default.
- W2344050635 hasConcept C159654299 @default.
- W2344050635 hasConcept C163864487 @default.
- W2344050635 hasConcept C203014093 @default.
- W2344050635 hasConcept C2776364478 @default.
- W2344050635 hasConcept C2776391228 @default.
- W2344050635 hasConcept C2777250017 @default.
- W2344050635 hasConcept C2779338263 @default.
- W2344050635 hasConcept C2781038049 @default.
- W2344050635 hasConcept C2908647359 @default.
- W2344050635 hasConcept C2908711476 @default.
- W2344050635 hasConcept C50440223 @default.
- W2344050635 hasConcept C542903549 @default.
- W2344050635 hasConcept C71924100 @default.
- W2344050635 hasConcept C90924648 @default.
- W2344050635 hasConcept C99454951 @default.
- W2344050635 hasConceptScore W2344050635C121608353 @default.
- W2344050635 hasConceptScore W2344050635C126322002 @default.
- W2344050635 hasConceptScore W2344050635C143998085 @default.
- W2344050635 hasConceptScore W2344050635C159654299 @default.
- W2344050635 hasConceptScore W2344050635C163864487 @default.
- W2344050635 hasConceptScore W2344050635C203014093 @default.
- W2344050635 hasConceptScore W2344050635C2776364478 @default.
- W2344050635 hasConceptScore W2344050635C2776391228 @default.
- W2344050635 hasConceptScore W2344050635C2777250017 @default.
- W2344050635 hasConceptScore W2344050635C2779338263 @default.
- W2344050635 hasConceptScore W2344050635C2781038049 @default.
- W2344050635 hasConceptScore W2344050635C2908647359 @default.
- W2344050635 hasConceptScore W2344050635C2908711476 @default.
- W2344050635 hasConceptScore W2344050635C50440223 @default.
- W2344050635 hasConceptScore W2344050635C542903549 @default.
- W2344050635 hasConceptScore W2344050635C71924100 @default.
- W2344050635 hasConceptScore W2344050635C90924648 @default.
- W2344050635 hasConceptScore W2344050635C99454951 @default.
- W2344050635 hasIssue "15_suppl" @default.
- W2344050635 hasLocation W23440506351 @default.
- W2344050635 hasOpenAccess W2344050635 @default.
- W2344050635 hasPrimaryLocation W23440506351 @default.
- W2344050635 hasRelatedWork W1980222117 @default.
- W2344050635 hasRelatedWork W2006471488 @default.
- W2344050635 hasRelatedWork W2132758759 @default.
- W2344050635 hasRelatedWork W2148963149 @default.
- W2344050635 hasRelatedWork W2161771249 @default.
- W2344050635 hasRelatedWork W2552000281 @default.
- W2344050635 hasRelatedWork W2562721404 @default.
- W2344050635 hasRelatedWork W2612832290 @default.
- W2344050635 hasRelatedWork W2995460854 @default.
- W2344050635 hasRelatedWork W4200090310 @default.
- W2344050635 hasVolume "28" @default.
- W2344050635 isParatext "false" @default.
- W2344050635 isRetracted "false" @default.
- W2344050635 magId "2344050635" @default.
- W2344050635 workType "article" @default.